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Description of the medicine: Citalopram (Citalopram)

CITALOPRAM (Citalopram).

1- [3- (Dimethylamino) propyl] -1- (p-fluorophenyl) -5-phthalanecarbonitrile.

Synonyms: Cipramil, Cipral, Cipramil, Lupram, Sepram.

Refers to a "balanced" antidepressants with a predominance of anxiolytic action.

Along with selective inhibition of neuronal uptake of serotonin, it blocks histamine, m-choline and adrenoreceptors.

When administered, the bioavailability is 80%, Cmax - 2-4 hours, T1 / 2 - 36 hours; undergoes biotransformation in the liver, inhibits the activity of cytochrome P 450; excreted in urine and feces.

Used for depression of various etiologies and structures.

It is prescribed for adults 0.02-0.06 g (20-60 mg) once a day, for the elderly 0.02-0.04 g (20-40 mg) per day. The antidepressant effect develops slowly (after 2-4 weeks).

Possible side effects: drowsiness, urination disorders, tremors, convulsive reactions, tachycardia, orthostatic hypotension, migraine, allergic reactions, etc.

The drug is contraindicated in pregnancy and lactation.

In connection with the ability to reduce the concentration of attention and the speed of reactions, it should be used with caution to persons driving vehicles and working with dangerous mechanisms.

Enhances the effects of sumatriptan and other serotonergic, as well as MAO inhibitors (possible hypertensive crisis).

Release form: tablets on 0,02 and 0,04 g (20 and 40 mg) (N. 14, 28).

Storage: List B.