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Description of the medicine: Citalopram (Citalopram)

CITAPROM (Citalopram).

1- [3- (Dimethylamino) propyl] -1- (p-fluorophenyl) -5-phthalanecarbonitrile.

Synonyms: Cipramil, Cipral, Cipramil, Lupram, Sepram.

Refers to "balanced" antidepressants with predominance of anxiolytic action.

Along with selective inhibition of neuronal seizure of serotonin, it blocks histamine, m-cholino and adrenoreceptors.

When administered, the bioavailability is 80%, Cmax is 2-4 h, T1 / 2 is 36 h; Undergoes biotransformation in the liver, inhibits the activity of cytochrome P 450; Is excreted in urine and feces.

Applied with depression of different etiology and structure.

Assign adult adults 0.02-0.06 g (20-60 mg) 1 time per day, the elderly 0.02-0.04 g (20-40 mg) per day. The antidepressant effect develops slowly (after 2-4 weeks).

Possible side effects: drowsiness, frustration of urination, tremor, convulsive reactions, tachycardia, orthostatic hypotension, migraine, allergic reactions, etc.

The drug is contraindicated in pregnancy and lactation.

In connection with the ability to reduce concentration and speed of reactions, caution should be exercised by persons driving vehicles and working with dangerous machinery.

Strengthens the effects of sumatriptan and other serotonergic, as well as MAO inhibitors (a hypertensive crisis is possible).

Form release: tablets of 0.02 and 0.04 g (20 and 40 mg) (N. 14, 28).

Storage: List B.