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Medication Description: Citalopram

CITALOPRAM (Citalopram).

1- [3- (Dimethylamino) propyl] -1- (p-fluorophenyl) -5-phthalanocarbonitrile.

Synonyms: Tsipramil, Cipral, Cipramil, Lupram, Sepram.

Refers to "balanced" antidepressants with a predominance of anxiolytic action.

Along with the selective inhibition of neuronal serotonin uptake, it blocks histamine, m-choline and adrenoreceptors.

When ingestion bioavailability is 80%, Cmax - 2-4 hours, T1 / 2 - 36 hours; undergoes biotransformation in the liver, inhibits the activity of cytochrome P 450; excreted in urine and feces.

Apply with depression of various etiologies and structures.

Assign inside adults 0.02-0.06 g (20-60 mg) 1 time per day, the elderly 0.02-0.04 g (20-40 mg) per day. The antidepressant effect develops slowly (after 2-4 weeks).

Possible side effects: drowsiness, urination disorders, tremor, convulsive reactions, tachycardia, orthostatic hypotension, migraine, allergic reactions, etc.

The drug is contraindicated in pregnancy and lactation.

Due to the ability to reduce concentration and reaction speed, it should be used with caution by those driving a vehicle and working with dangerous machinery.

Enhances the effects of sumatriptan and other serotonergic, as well as MAO inhibitors (possible hypertensive crisis).

Product form: tablets of 0.02 and 0.04 g (20 and 40 mg) (N. 14, 28).

Storage: List B.