Description of the medicine: Articaine
4-Methyl-3- [2- (propylamino) propionamido] -2-thiophenecarboxylic acid methyl ester.
Synonyms: Alfacaine, Brilocaine, Septanest, Ubistesin Fort, Ultracaine, Alphacaine, Ultracaine.
White or white with a creamy hue of crystalline powder. Soluble in water and alcohol.
Has a fast and relatively long (1-3 hours) local anesthetic effect.
With intramuscular injection, C max is 20-4 min, T S is 40 min; Undergoes biotransformation in the liver, is excreted by the kidneys.
Applied with infiltration, conductor, spinal and lumbar anesthesia.
Ultrakain is used mainly in general surgical practice, alfacaine N and JV, brilocaine - in general surgical and dental, and ultracaine D-C and D-C forte, septanest with adrenaline - in the dental.
In dentistry it is used for operations on the mucous membrane or bone, on the tooth pulp, with the removal of the tooth, percutaneous osteosynthesis, cystectomy, mukogingival operations.
For infiltration anesthesia use 1% solution of articaine (5-20 ml) with adrenaline (1: 200 000) and without it, for conductive blockade and epidural anesthesia - 1-2% solution (0.4-0.6 g) and for Spinal - 5% solution (0.1-0.15 g) based on 10% glucose solution.
The maximum single dose of 0.4 and 0.6 g respectively without and with the addition of epinephrine.
When using articaine, side effects are possible: headache, blurred vision, diplopia, muscle twitching; In rare cases - a violation of consciousness. There are also allergic reactions - swelling and redness of the skin at the injection site, angioedema, etc.
The drug is contraindicated in bronchial asthma, arrhythmias, closed-angle glaucoma.
Forms of release: 1% and 2% solutions for injections in ampoules of 5 and 20 ml (Ultrakain); Injection for articaine containing 0.04 g (40 mg) and adrenaline bitartrate 1: 200,000 (Alfacaine H) or 1: 100,000 (Alfacaine SP) - in cartridges of 1.8 ml each; Injection solution containing articaine 0.06 g (60 mg) and epinephrine 1: 100,000 and 1: 200,000, in 1.8 ml cartridges (Septnast with epinephrine); Solution for injection, containing 1.04 ml of articaine 0.04 g and epinephrine 0.006 mg (Ultracaine D-C) or 0.012 mg (Ultracaine D-C Fort), in the cartridges of 1.7 ml.