Medication Description: Articaine (Articaine)
Methyl 4-methyl-3- [2- (propylamino) propionamido] -2-thiophenecarboxylic acid.
Synonyms: Alfacain, Brilokain, Septanest, Ubucinecin Forte, Ultracain, Alphacaine, Ultracaine.
White or white with a creamy tinge crystalline powder. Soluble in water and alcohol.
It has a quick and relatively long (1-3 hours) local anesthetic effect.
With intramuscular administration, C max is 20-4 min, T Ѕ is 40 min; Biotransformation in the liver, excreted by the kidneys.
Applied with infiltration, conduction, spinal and lumbar anesthesia.
Ultracain is used mainly in general surgical practice, Alfacain H and SP, Brilloquin - in general surgical and dental, and Ultracain D-C and D-C forte, septanest with adrenaline - in the dental.
In dentistry, they are used in operations on the mucous membrane or bone, on the pulp of a tooth, during tooth extraction, percutaneous osteosynthesis, cystectomy, and muco-ningival operations.
For infiltration anesthesia, use 1% solution of articaine (5-20 ml) with adrenaline (1: 200 000) and without it, for conduction blockade and epidural anesthesia - 1-2% solution (0.4-0.6 g) and for spinal - 5% solution (0.1-0.15 g) based on 10% glucose solution.
The maximum single dose of 0.4 and 0.6 g, respectively, without and with the addition of adrenaline.
The use of articaine possible side effects: headache, blurred eyes, diplopia, muscle twitching; in rare cases - a violation of consciousness. Allergic reactions are also likely - swelling and redness of the skin at the injection site, angioedema, etc.
The drug is contraindicated in bronchial asthma, arrhythmias, angle-closure glaucoma.
Forms of release: 1% and 2% solutions for injections in 5 and 20 ml ampoules (Ultracain); injection solution containing articaine 0.04 g (40 mg) and epinephrine bitartrate 1: 200 000 (Alfacain H) or 1: 100 000 (Alfacain SP) - 1.8 ml in patrons (cartridges); injection solution containing articaine 0.06 g (60 mg) and adrenaline 1: 100 000 and 1: 200 000, in patrons 1.8 ml (Septanest with adrenaline); injection solution containing in 1 ml of articaine 0.04 g and adrenaline 0.006 mg (Ultracain D-C) or 0.012 mg (Ultracain D-C forte), in patrons 1.7 ml.