Description of the medicine: Bisoprolol (Bisoprolol)
(±) -1 - [[α- (2-Isopropoxyethoxy) p-tolyl] oxy] -3- (isopropylamino) -2-propanol.
Synonym: Concor, Concor.
White crystalline powder. Very soluble in water, methanol and ethanol.
Cardioselective β1-blocker long-acting. It does not possess membrane stabilizing and partial agonistic activity. Does not affect lipid metabolism.
Bioavailability is 80%, C max is 2-4 h, T S is 9-12 h; Excreted mainly by the kidneys.
The main indications: arterial hypertension, angina pectoris, postinfarction period.
They are also used in the complex therapy of chronic heart failure.
Is taken orally, without chewing and drinking with water, in the morning on an empty stomach or during breakfast.
As an antihypertensive and antianginal agent, usually 0.005-0.01 g (5-10 mg) is administered once a day.
Antihypertensive effect develops 3-4 hours after admission and lasts more than 24 hours.
For chronic heart failure, starting from 0.00125 g (1.25 mg) per day and gradually increasing the dose every 1.25 mg (doses of 5 and 7.5 mg take for 4 weeks) to a maximum of 0.01 g (10 mg).
According to the data published in the foreign medical literature, the use of bisoprolol for 1 year resulted in a significant reduction in the incidence of total mortality, sudden mortality and the number of hospitalizations in patients with severe chronic heart failure (who were on permanent treatment with ACE inhibitors, diuretics and if necessary with cardiac glycosides). Similar results were obtained in patients who survived myocardial infarction.
Possible side effects, contraindications and restrictions to use are the same as in other β-blockers (see Anaprilin and Atenolol).
Antagonists of calcium ions, amiodarone, cardiac glycosides, class I antiarrhythmics, reserpine, methyldopa increase the risk of side effects from the heart.
Form release: tablets of 0.005 and 0.01 g (5 and 10 mg) (N. 30, 50, 100).
Storage: List B.