Medication Description: Midantan (Midantanum)
MIDANTANUM. 1-Amino adamantane hydrochloride, or 1-adamantanamine hydrochloride.
Synonyms: Virigit, Adamantin, Amandin, Amantadini hydrochloridum, Amantadine hydrochoride, Amantan, Antadine, Atarin, Fluviatol, Gabirol, Mantadix, Mydantan, Paramentin, Protexin, Symmetrel, Viregit, Virofral, Virosol, etc.
White crystalline powder bitter taste. Let's dissolve in water, it is easy - in alcohol.
The drug was originally proposed as an antiviral agent effective against influenza A viruses. Later, its effectiveness in parkinsonism was discovered.
The mechanism of the therapeutic action of midanthan in parkinsonism is explained by the fact that it stimulates the release of dopamine from the neuronal depot and increases the sensitivity of dopaminergic receptors to the mediator (dopamine); Thus, even with a decrease in the formation of dopamine in the basal ganglia, conditions are created for the normalization of the neurophysiological processes occurring in them. There is also evidence that midantan inhibits the generation of impulses in the motor neurons of the central nervous system.
Apply Midantan with Parkinson's disease and parksinsonism of different etiology. The drug is mainly effective in case of rigid and akinetic forms, less affecting the hyperkinetic syndrome (tremor).
Information about the effectiveness of Midantan as a corrector of neuroleptic syndrome is contradictory. According to some authors, the drug can be used for this purpose, according to others, its use is inexpedient, since it is ineffective in medium doses, and in large doses it can cause exacerbation of psychopathological symptoms.
Midantan is a fast-acting drug, the effect usually occurs in the first days of treatment.
The drug can be prescribed independently and in combination with other antiparkinsonic drugs: anticholinergics and L-Dov.
Assign midantan inside after eating. Accept, starting with 0.05 - 0.1 g, first 2 times, then 3 - 4 times a day. Daily doses of 0.2 - 0.4 g. Duration of treatment 2 - 4 months.
The drug is usually well tolerated. In some cases, there may be headache, insomnia, dizziness, general weakness, dyspeptic symptoms. If necessary, reduce the dose.
Milantan is contraindicated in acute and chronic diseases of the liver and kidneys, as well as during pregnancy. In connection with the possible excitation of the central nervous system, the drug should be prescribed with caution in patients with mental illness, thyrotoxicosis, epilepsy.
Form release: tablets of 0.1 g, coated yellow, in a package of 100 pieces.
Storage: List B. In a dry place.
R p.: Tab. Midantani 0.1 obd. N. 100