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Description of the medicine: Terazosin (Terazosin)

Terazosin (Terazosin).

1- (4-amino-6,7-dimethoxy-2-quinazolinyl) -4- (tetrahydro-2-furoyl) piperazine hydrochloride.

Synonyms: Kornam, Setegis, Heitrin, Cornam, Hytrin, Setegis.

White crystalline powder. It is soluble in water.

The chemical structure is very close to prazosin, it differs only in the replacement of the furan cycle with the tetrahydrofuran one.

It blocks the postsynaptic A1-adrenergic receptors of the vessels, prostate and bladder for a long time.

Quickly and completely absorbed in the digestive tract, bioavailability exceeds 90%, Cmax is 1 hour, T1 / 2 - 12 hours, in connection with which the drug is prescribed 1 time per day; undergoes biotransformation in the liver, excreted mainly with feces.

Applied for the treatment of arterial hypertension and benign prostatic hyperplasia (see Prazosin).

With arterial hypertension, it is prescribed starting from 0.001 g (1 mg) orally at night (in the supine position), then the dose is gradually increased to 0.005-0.01 g (5-10 mg) per day, monitoring the effectiveness and tolerability.

With prostatic hypertrophy, initially also prescribed in a dose of 0.001 g (1 mg) at night, then 0.002-0.01 g (2-10 mg) per day.

Possible side effects and precautions are the same as with prazosin.

Release form: tablets on 0,001; 0.002; 0.005 and 0.01 g (1; 2; 5; and 10 mg) (N. 10, 20, 28).

Storage: List B.