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Description of the medicine: Terfenadine (Terfenadine)

TERFENADINE (Terfenadine).

α- (para-tert-Butylphenyl) -4- (oxydiphenylmethyl) -1-piperidylbutanol.

Synonyms: Bronal, Histadine, Dailert, Caradonel, Rapidal, Riter, Tamagon, Teldan, Teridin, Terfed, Terfena, Tofrin, Treksil, Bronal, Caradonel, Daylert, Histadine, Rapidal, Riter, Seldane, Tamagon, Teridine, Termenadin, Triludan, Tofrin, Toldan, Trexyl, etc.

White or whitish crystalline powder. It is poorly soluble in water, slightly soluble in chloroform, soluble in alcohol.

Blocker of H 1 histamine receptors. It has a weak m-choinoblocking effect.

It does not have a pronounced sedative effect.

When ingested, it is well absorbed (about 70%), C max is 1 hour, does not penetrate the blood-brain barrier; undergoes intensive biotransformation in the liver with the formation of the active metabolite fexofenadine (see), excreted in urine and feces.

The antihistamine effect develops after 1-2 hours, reaches a maximum after 3-4 hours and lasts (after a single use) for about 12 hours.

Indications for use are the same as for other H 1 receptor blockers (allergic rhinitis and conjunctivitis, Quincke's edema, contact dermatitis, dermatoses, allergic reactions when taking drugs, etc.).

Assign inside adults and children over 12 years old at 0.06 g (60 mg) 2 times a day or 0.12 g once in the morning; the maximum daily dose of 0.48 g. Children from 6 to 12 years of age are prescribed 0.03 g 2 times a day.

When using the drug in some cases, erythema, galactorrhea, headache, fatigue, dizziness, drowsiness, dry mucous membranes, nausea, vomiting, increased appetite are observed, and when the dose is exceeded, ventricular arrhythmias (including pirouette type tachycardia).

Contraindications: pregnancy and lactation.

Method of release: tablets of 0.06 and 0.12 g (60 and 129 mg) (N. 10, 20); 0.6% suspension for oral administration (0.03 g (30 mg) in 1 teaspoon).

Storage: List B.