Medication Description: Terfenadine (Terfenadine)
α- (para-tert-Butylphenyl) -4- (oxyphenylmethyl) -1-piperidylbutanol.
Synonyms: Bronal, Histadin, Daylert, Caradonell, Rapidal, Ryter, Tamagon, Teldan, Teridin, Terfed, Terfen, Tofrin, Trexil, Bronal, Caradonel, Daylert, Histadine, Rapidal, Riter, Seldane, Tamagon, Teridine, Termeant, Histadine, Rapidal, Riter, Seldane, Tamagon, Teridine, Termen, Histadine, Rapidal, Riter, Seldane Triludan, Tofrin, Toldan, Trexyl, etc.
White or whitish crystalline powder. Poor soluble in water, lightly in chloroform, soluble in alcohol.
The blocker H 1 -histamine receptors. It has a weak mo-blocking effect.
Does not have a pronounced sedative effect.
When ingestion is well absorbed (about 70%), C max is 1 h, does not penetrate the blood-brain barrier; subjected to intense biotransformation in the liver with the formation of the active metabolite of fexofenadine (see), excreted in the urine and feces.
Anti-histamine effect develops in 1-2 hours, reaches a maximum in 3-4 hours and lasts (after a single use) about 12 hours.
Indications for use are the same as for other H 1 -receptor blockers (allergic rhinitis and conjunctivitis, angioedema, contact dermatitis, dermatosis, allergic reactions when taking drugs, etc.).
Assign inside adults and children over 12 years old to 0.06 g (60 mg), 2 times a day or 0.12 g once in the morning; the maximum daily dose is 0.48 g. Children from 6 to 12 years old are prescribed 0.03 g 2 times a day.
When using the drug in some cases, erythema, galactorrhea, headache, fatigue, dizziness, drowsiness, dry mucous membranes, nausea, vomiting, increased appetite are observed, and if the dose is exceeded, ventricular arrhythmias (including pirouette tachycardia) are observed.
Contraindications: pregnancy and breastfeeding.
Method of production: tablets of 0.06 and 0.12 g (60 and 129 mg) (N. 10, 20); 0.6% suspension for oral administration (0.03 g (30 mg) in 1 teaspoon).
Storage: List B.