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Description of the medicine: Triazolam (Triazolam)

TRIAZOLAM (Triazolam). 8-Chloro-6- (ortho-chlorophenyl) -1-methyl-1H-S-triazolo- [4, 3a] [1, 4] benzodiazepine.

Synonyms: Somneton, Halzion, Clorazolam, Halcion, Insomnium, Novidorm, Nuctan, Somneton, Songar, etc.

In structure, triazolam is close to alprazolam (see), differs from it only in the presence of a C 1 atom with a phenyl nucleus at position 6. In action, these drugs differ from each other. Triazolam has a pronounced hypnotic effect and in this regard is close to nitrazepam, while alprazolam is closer in spectrum of action to tranquilizers.

Compared with nitrazepam, triazolam acts in smaller doses. Its effective hypnotic dose is 0.25-0.5 mg. It is rapidly absorbed when taken orally and is relatively rapidly excreted from the body. The elimination half-life makes 1, 5 - 3 hours. Triazolamum acts shorter, than nitrazepamum. Daytime drowsiness and other side effects are less pronounced than when taking nitrazepam, however, when using triazolam, the same precautions must be followed as with nitrazepam. It should be borne in mind that triazolam is a relatively new drug, and therefore its uncontrolled use cannot be allowed.

Release form: tablets of 0.25 mg (blue) and 0.5 mg (white).

Storage: List B.

Abroad, some other benzodiazepine derivatives, similar in structure to benzodiazepine tranquilizers, are also used as sleeping pills.

Flurazepam (Flurazepam). Synonyms: Benozil, Dalmador, Dalmane, Dormodor, Enoctan, Fludan, Fluzepam, Insumin, Lunipax, Noctosom, Novoflupam, Valdorm, etc.

Lorazepam (Lorazepam). Synonyms: Аlmazin, Аmparax, Аnsilor, Аtivan, Сalmogenol, Duralozam, Larotensil, Lorsedal, Modelral, Sedatival, Tolid, Tranquipan, etc.

Temazepam (Temazepam). Synonyms: Cerepax, Lenal, Levanxol, Methyloxazepam, Normijon, Remastan, Temazepax, Temazin, Tonirem, etc.

These drugs are similar in structure and effect to nitrazepam (a fluorine atom is contained in the flurazepam molecule). They differ in absorption rate, duration of action, effective doses.

Flurazepam is absorbed rapidly but is excreted slowly; the half-life (together with the active metabolite) is 50 to 100 hours. An effective hypnotic dose is 15 to 30 mg.

Lorazepam is absorbed more slowly, elimination half-life - 10 - 20 hours; dose of 2-4 mg.

Temazepam is absorbed slowly, elimination half-life of 10 - 17 hours; dose of 15-30 mg.