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Description of the medicine: Ramipril (Pamipril)

RAMIPRIL (Pamipril).

1 - [[1-Carboxy-3-phenylpropyl] -alanyl] octahydro-cyclopenta [b] -pyrrole-2-carboxylic acid ethyl ester.

Synonyms: Korpil, Tritace, Altace, Corpril, Tritace.

White crystalline powder. Soluble in organic solvents and buffer aqueous solutions.

Alanine-containing long-acting ACE inhibitor (more than 24 hours). On the basic pharmacological properties is similar to other ACE inhibitors.

Is a prodrug; After oral administration, it is metabolized in the liver to the active metabolite ramiprilate.

When ingested 50-60% of the dose is absorbed, C max is 1-4 hours; Excreted in urine and feces.

Applied with arterial hypertension, congestive heart failure, after myocardial infarction and with diabetic nephropathy. Individual patients are prescribed for the prevention of myocardial infarction, strokes, prevention of death from cardiovascular diseases and the need for myocardial revascularization.

According to data published abroad, in patients with atherosclerosis of peripheral vessels (without arterial hypertension, chronic heart failure and myocardial infarction in the anamnesis), the long-term (5 years) use of ramipril led to a reduction in the frequency of deaths, primary myocardial infarctions, strokes and heart failure.

Reduction of mortality was also noted when taking ramipril in patients with IHD with acute myocardial infarction and heart failure.

For arterial hypertension and congestive heart failure, apply (inside) from 0.00125 g (1.25 mg) 1 time per day, if necessary, the daily dose is increased with an interval of 1-2 weeks to 0.01 g (with heart failure it Can be divided into 2 receptions).

Postinfarction patients are prescribed in the first 2 days to 0,00125-0,0025 g (1,25-2,5 mg) 2 times a day, and then 0,005 g 2 times a day.

To prevent myocardial infarction, strokes, death from cardiovascular diseases and the need for myocardial revascularization in individual cases, 0.0025 g (2.5 mg) is administered once a day for 1 week, then 0.005 g (5 mg) - 3 weeks and further on 0,01 g (10 mg).

Possible side effects and contraindications are the same as in enalapril.

Forms of release: capsules and tablets of 0.00125; 0.0025 and 0.005 g (1.25, 2.5 and 5 mg) (N. 14, 28).