Before taking the course, consult a doctor!
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Description of the medicine: Fosinopril (Fosinopril)
FOSINOPRIL.
(4S) -4-Cyclohexyl-1 - [[R - [(S) -1-hydroxy-2-methylpropoxy] (4-phenylbutyl) phosphinyl] acetyl] -L-proline propionate.
Available in the form of sodium salt.
Synonyms: Daynacil, Monopril, Old, Fosinorm, Monopril.
White or off-white crystalline powder. Soluble in water, methanol and ethanol.
Contains in the molecule the residue of L-proline (like lisinopril) and at the same time the phosphinyl group (= P = O).
It is a prodrug, in the body it turns into an active metabolite fosinoprilat.
From other ACE inhibitors, fosinopril is better for lowering the level of endothelin in the blood, which is a potent vasoconstrictor factor and a vascular remodeling factor.
When taken orally absorbed almost completely, bioavailability is about 40%, C max - 3 h, T S - 11.5 h; Is excreted in the urine and bile.
Applied with arterial hypertension and chronic heart failure.
According to published data in the foreign literature, in patients who survived myocardial infarction, long-term (2 years) fosinopril administration resulted in a reduction in the incidence of fatalities and cases of severe heart failure.
Assign inside by 0.01 g (10 mg) 1 time per day. If necessary, the dose is gradually increased to 0.02-0.04 g (20-40 mg) per day.
Possible side effects: dyspepsia, cough, bronchospasm, angioedema, pain in the chest, muscles and joints; Orthostatic hypotension, palpitations, arrhythmias, proteinuria, oliguria, photosensitivity, skin itching.
The drug is contraindicated in pregnancy, breast-feeding and in childhood.
Form release: tablets of 0.01 and 0.02 g (10 and 20 mg) (N. 10, 14, 20, 28).
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