Description of the medicine: Fosinopril (Fosinopril)
(4S) -4-Cyclohexyl-1 - [[R - [- (S) -1-hydroxy-2-methylpropoxy] (4-phenylbutyl) phosphinyl] acetyl] -L-proline propionate.
Available in the form of sodium salt.
Synonyms: Dinacyl, Monopril, Staril, Fozinorm, Monopril.
White or off-white crystalline powder. Soluble in water, methanol and ethanol.
Contains the remainder of L-proline in the molecule (like lisinopril) and at the same time a phosphinyl group (= P = O).
It is a prodrug, in the body turns into an active metabolite fosinoprilat.
Fosinopril differs from other ACE inhibitors for the better in its ability to lower blood levels of endothelin, which is a powerful vasoconstrictor factor and vascular remodeling factor.
When taken orally, it is absorbed almost completely, bioavailability is about 40%, C max - 3 hours, T Ѕ - 11.5 hours; excreted in urine and bile.
Used for arterial hypertension and chronic heart failure.
According to data published in foreign literature, in patients who survived myocardial infarction, prolonged (2 years) administration of fosinopril led to a decrease in the frequency of deaths and cases of severe heart failure.
Assign inside of 0.01 g (10 mg) once a day. If necessary, the dose is gradually increased to 0.02-0.04 g (20-40 mg) per day.
Possible side effects: dyspepsia, cough, bronchospasm, angioedema, pain in the chest, muscles and joints; orthostatic hypotension, palpitations, arrhythmias, proteinuria, oliguria, photosensitivity, pruritus.
The drug is contraindicated in pregnancy, breastfeeding and in childhood.
Release form: tablets of 0.01 and 0.02 g (10 and 20 mg) (N. 10, 14, 20, 28).