Before taking the course, consult a doctor!
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Description of the medicine: Apraclodidine (Apraclonidine)
APRAKLODININ (Apraclonidine).
2 - [(4-Amino-2,6-dichlorophenyl) imino] imidazolidine hydrochloride.
Synonym: Iopidine, Iopidine.
Chemically, it differs from clonidine only in the content of the amino group in the para position of the phenyl nucleus.
Apraclonidine belongs to the group of stimulants (agonists) of α 2 -adrenoceptors.
It is applied (in the form of eye drops) to reduce intraocular pressure in glaucoma (reduces mainly the secretion of watery eyes). In contrast to clonidine (clonidine) does not have a pronounced systemic effect: does not significantly affect the cardiovascular system, does not show much sedative effect.
It is prescribed mainly for otkrutougolnoy glaucoma as an additional remedy with insufficient effectiveness of other drugs.
Apply one drop of 0.5% solution 2-3 times a day. The effect after a single instillation occurs within 1 h; The peak of the action is in 5-6 hours.
Possible side effects: allergic reactions (redness of the conjunctiva, itching, swelling), dry mouth; With hypersensitivity are likely violations of coordination of movements, arrhythmias.
It should be noted that in patients with glaucoma who are already using drugs that reduce the secretion of watery moisture (β-blockers, inhibitors of carbonic anhydrase), apraklonidine is sometimes not used to reduce intraocular pressure, since its mechanism of action is also associated with inhibition of secretion.
Form release: 0.5% solution (eye drops) in bottles of 5 ml. (It also produces 1% solution for segmental laser surgery.)
Note. Apraklonidine was created in the late 1980s. In some countries (including the United States, France, etc.), he has already entered medical practice, while others (for example, in Russia) continue his in-depth clinical study.
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