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Description medications: valsartan (Valsartan)

Valsartan (Valsartan).

N- [p- (o-1H-tetrazol-5-ylphenyl) benzyl] -N-valeryl-L-valine.

Synonym: Diovan, Diovan.

By chemical structure similar to losartan (by phenyl-tetrazolyl-benzyl moiety), but includes the amino acid residue in the molecule (L- valine).

In action as close to losartan.

Rapidly absorbed in the digestive tract, bioavailability of about 20%, C max - 2 hours, T ½ of about 9 hours; excreted from the body mostly unchanged in the urine and bile.

Provides long-term antihypertensive effect (after a single oral administration of the effect lasts up to 24 hours), which is associated with irreversible blockade of AT1 receptors -angiotenzinovyh.

Applied for the treatment of hypertension and congestive heart failure.

Assign into tablets of 0.08 g (80 mg), 1 time per day (up to 0.16 g). Sustained reduction in blood pressure is usually observed within 2 weeks; long-term treatment with anti-hypertensive effect is enhanced.

The drug is relatively well tolerated, but there may be headache, dizziness, nausea, diarrhea. Fairly rare (compared with ACE inhibitors), dry cough develops.

Contraindications: pregnancy and breast-feeding.

Product: capsules of 0.08 and 0.16 g (N. 28).

Co-diovan - Tablets containing 0.08 g (80 mg) and 0.0125 g of valsartan (12.5 mg), hydrochlorothiazide.