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Description of the medicine: Candesartan (Candesartan)

CANDESARTAN (Candesartan).

(±) 1H-Benzimidazole-7-carboxylic acid 2-ethoxy-1 - [[2 '- (H-tetrazol-5-yl) [1,1'-biphenyl] 4-yl] methyl] -1 - [[ cyclohexyloxy] carbonyl] oxy] ethyl ether.

Synonym: Atacand, Atacand.

In structure (the presence of a tetrazolyl-phenyl-benzyl fragment) is similar to losartan.

Compared with losartan and valsartan, it is more active.

When administered, the bioavailability is about 40%, C max - 3-4 hours, T 9 - 9 hours; partially subjected to biotransformation in the liver, excreted mainly with bile.

Assign inside as an antihypertensive agent at 0.004-0.008 g (4-8 mg) 1 time per day.

The maximum antihypertensive effect usually develops 4 weeks after the start of treatment.

Side effects (headache, back and muscle pain, dizziness, nausea, impaired liver function tests) are rare.

Contraindications: severe liver dysfunction, cholestasis, breast-feeding.

Release form: tablets on 0,004; 0.008 and 0.016 g (4, 8 and 16 mg) (N. 14, 100).

Storage: List B.