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Description of the medicine: Candesartan

Candesartan.

(±) 1H-Benzimidazole-7-carboxylic acid 2-ethoxy-1 - [[2 '- (H-tetrazol-5-yl) [1,1'-biphenyl] 4-yl] methyl] -1 - [[ Cyclohexyloxy] carbonyl] oxy] ethyl ester.

Synonym: Atacand, Atacand.

By structure (the presence of the tetrazolyl-phenyl-benzyl moiety) is similar to losartan.

Compared with losartan and valsartan is more active.

When administered, the bioavailability is about 40%, C max is 3-4 h, T S is 9 h; Partially exposed to biotransformation in the liver, is excreted mainly with bile.

Assign inside as an antihypertensive agent to 0,004-0,008 g (4-8 mg) 1 time per day.

The maximum antihypertensive effect develops usually 4 weeks after the start of treatment.

Side effects (headache, back and muscle pain, dizziness, nausea, disturbance of liver tests) occur rarely.

Contraindications: severe violations of the liver, cholestasis, breast-feeding.

Product: pills to 0,004; 0.008 and 0.016 g (4, 8 and 16 mg) (N. 14, 100).

Storage: List B.