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Description drugs: moxonidine (Moxonidine)

Moxonidine (Moxonidine).

4-Chloro-5- (2-imidazolin-2-ylamino) -6-methoxy-2-methylpyrimidine.

Synonyms: Fiziotenz, Cynthia, Cynt, Phisiotens.

Stimulator (agonist) imidazoline central receptors modulating the tonic and reflex (inhibitory) effect on the sympathetic nervous system, and to a lesser - of pre- and postsynaptic α 2 -adrenoceptor.

When ingestion rapidly and almost completely absorbed, bioavailability of approximately 90%, C max - 30-180 minutes, the T ½ - 2-3 hours (although the duration of action after a single dose up to 24 hours); excreted by the kidneys mostly unchanged.

Apply for various types of hypertension. The most effective in patients with mild to moderate hypertension.

Assign inside 0,0002-0,0004 g doses (0.2 - 0.4 mg) once daily (or 0.0002 g in 2 hours); if necessary, increase the dose to 0.0006 grams per day (2-3 hours). It can be used together with saluretikami (hydrochlorothiazide).

The drug is generally well tolerated (better than clonidine and methyldopa). Possible side effects: dizziness, headache, dry mouth (early treatment), lower limb swelling, mild drowsiness. Sedating effect has not. Withdrawal is usually not observed.

The drug is contraindicated in angioedema in history, the syndrome sick sinus, violations of intracardiac conduction, bradycardia, severe arrhythmias, unstable angina, severe heart failure, expressed violations of the liver and kidneys, disorders of peripheral blood circulation, depression, epilepsy, glaucoma, pregnancy, breast breast, under the age of 16 years.

(Mutually) the effect of other antihypertensive drugs, as well as substances which depress the central nervous system.

When receiving moxonidine is necessary to eliminate the use of alcohol is not recommended (especially at the beginning of treatment) using machinery that requires attention and speed of reaction.

Product: pills to 0.0002; 0.0003 and 0.0004 g (0.2; 0.3 and 0.4 mg) (N. 10, 14, 20).

Storage: List B.