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Description medications: pravastatin (Pravastatin)

Pravastatin (Pravastatin).

Hexahydro-β, δ, 6-trihydroxy-2-methyl-8- (z-methyl-1-oxo-butoxy) -1-naftalingeptanoevoy acid sodium salt.

Synonym: Lipostat, Lipostat.

White or colorless crystalline powder. It is soluble in water, poorly - in isopropanol, practically insoluble in acetone, chloroform, and acetonitrile.

The chemical structure and mechanism of action similar to lovastatinu and other statins. The body acts entire molecule (unlike lovastatin).

In the digestive tract is absorbed not fully (up to 54% of the dose), C max is 1-1.5 hours, the T ½ - about 77 hours; biotransformation in the liver, mainly in faeces.

Assign with type II hyperlipidemia without coronary artery disease, atherosclerosis, ischemic heart disease (including myocardial infarction), and familial hypercholesterolemia.

According to published foreign data, in patients with coronary artery disease and hypercholesterolemia in long-term (up to 3 years) pravastatin application along with a marked reduction in cholesterol-lowering effect was observed progression of coronary atherosclerosis and the risk of complications (lower total and "cardiovascular" mortality, myocardial infarction). The drug was effective in primary prevention of coronary heart disease - in patients with severe hypercholesterolemia, but without evidence of cardiovascular disease has been a significant reduction in total and "coronary" mortality and nonfatal myocardial infarction.

Assign inside of 0.01-0.04 g (10-40 mg) per day (before bedtime). With an interval of at least 4 weeks produced a dose adjustment.

Possible side effects: exacerbation of pancreatitis, myopathy, arthralgia, hepatic dysfunction, acute renal failure on the background of rhabdomyolysis, decreased libido, progression of cataract, allergic reactions, etc.

Pravastatin is contraindicated in diseases of the liver, pregnancy and breastfeeding.

Macrolide antibiotics, nicotinic acid and other cholesterol-lowering drugs increase the risk of rhabdomyolysis with acute renal failure. Proximity effect anticoagulants.

Product: pills to 0.01 g and 0.02 g (N. 10, 20).