Medication Description: Apulein

Budesonidum.

Synonyms: Apulein, Benacort, Budesonide, Budenofalk, Gorakort, Pulmicort, Rhinocort, Cicortid Cyclocaps, Apulein, Budenofalk, Budesonide, Cycortid Cyclocaps, Goracort, Pulmicort, Rhinocort.

White or off-white powder. Virtually nerastvorim in water and heptane, sparingly soluble in ethanol, well - in chloroform.

Glucocorticosteroid drug, close in structure to triamcinolone acetonide, but differing in the absence of a fluorine atom in the molecule (and the replacement of methyl radicals in the acetonide group by hydrogen and propyl).

Due to its low absorption, it has no pronounced systemic effect, is better tolerated and, compared with fluorinated preparations, does not cause significant atrophic changes in the skin during prolonged use.

In inhalations, approximately 25% of the dose falls into the alveoli, C _{max is} 15-45 min, T _S is 2.8 h; Is excreted mainly by the kidneys.

Apply mainly locally: in the form of ointment (cream) - with atopic dermatitis, psoriasis, eczema and in the form of inhalations - with bronchial asthma and obstructive bronchitis. In the form of capsules for oral administration (Budenofalk) is proposed (as an anti-inflammatory drug) in Crohn's disease.

Inhalation adults are prescribed at the beginning (with exacerbation of bronchial asthma) 0.2-1.6 mg per day (in several doses), in less severe cases - 0.2-0.8 mg per day; Children over 7 years - 0.2-0.8 mg per day in 2-4 admission). After inhalation, thoroughly rinse throat.

Ointment is applied to the affected skin at the beginning 2 times and then 1 time per day.

Inside appoint in the form of capsules (without chewing, before eating) to 0,003 g (3 mg) 3 times a day.

Possible side effects: with topical application - hemorrhages, skin atrophy, dermatitis, folliculitis, hyperpigmentation, burning sensation, itching; With inhalations - dysphonia, cough, sore throat.

The drug is contraindicated in pregnancy and lactation; For inhalations - with tuberculosis, fungal infection of the respiratory system; For topical application - with skin infections, common lichen; For the introduction of the inside - with infections of the gastrointestinal tract, severe violations of the liver.

Forms of release: powder for inhalation (0.1 and 0.2 mg / dose, 100 and 200 doses) complete with inhaler (cyclo- or turbuhaler) and in capsules (0.2 mg / dose, 100 and 200 doses); 0.0125%; 0.025% and 0.05% suspension for inhalations in 2 ml containers (N. 4, 20); A metered aerosol for inhalations in cans of 10 ml (0.05 mg / dose - Budesonide-mite and 0.2 mg / dose - Budesonide-forte, 200 doses); 0.025% ointment and cream in tubes of 15 g; Capsules of 0.003 g (3 mg) (N. 10, 50).