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Description medicines: budesonide (Budesonidum)

Budesonide (Budesonidum).

Synonyms: Apulein, benacort, Budesonide, Budenofalk, Gorakort, Pulmicort, Rinokort, Tsikortid Tsiklokaps, Apulein, Budenofalk, Budesonide, Cycortid Cyclocaps, Goracort, Pulmicort, Rhinocort.

White or off-white powder. Practically insoluble in water and heptane, sparingly soluble in ethanol, good - in chloroform.

Glucocorticosteroids, similar in structure to triamcinolone acetonide, but absence wherein the fluorine atom in the molecule (and the replacement of the methyl radicals to hydrogen acetonide group and propyl).

Due to the low absorbability has expressed no systemic action and better tolerated as compared with fluorinated agents atrophic no significant changes in the skin with prolonged use.

When inhaled into the alveoli gets about 25% of the dose, C max of 15-45 minutes, the T ½ - 2.8 hours; excreted mainly by the kidneys.

Applied mostly locally: in an ointment (cream) - in atopic dermatitis, psoriasis, eczema and inhaled - in bronchial asthma and obstructive bronchitis. In capsule form for oral administration (Budenofalk) is proposed (as an anti-inflammatory agent) in Crohn's disease.

Inhalation adult appointed initially (during exacerbation of asthma) at 0.2-1.6 mg daily (in divided doses), in less severe cases - by 0.2-0.8 mg per day; Children older than 7 years - 0.2-0.8 mg per day in 2-4 doses). After inhalation Rinse thoroughly throat.

The ointment is applied to the affected areas of the skin first two times and then 1 times a day.

Inside administered in the form of capsules (not liquid, before meals) to 0,003 g (3 mg) three times a day.

Possible side effects: when applied topically - haemorrhages, atrophy of the skin, dermatitis, folliculitis, hyperpigmentation, burning sensation, itching; Inhalation - hoarseness, cough, sore throat.

The drug is contraindicated during pregnancy and lactation; for inhalation - for tuberculosis, fungal infections of the respiratory system; topical - in skin infections, herpes ordinary; for oral administration - with gastrointestinal infections, severe hepatic impairment.

Product: powder for inhalation (0.1 and 0.2 mg / dose, 100 and 200 doses) together with an inhaler (or cyclo- turbuhaler) and capsules (0.2 mg / dose, 100 and 200 doses); 0.0125%; 0.025% and 0.05% for inhalation suspension in 2 ml containers (N. 4, 20); metered aerosol inhalation in cans of 10 ml (0.05 mg / dose - budesonide-Mita and 0.2 mg / dose - Budesonide forte; 200 doses); 0.025% ointment and cream in tubes of 15 g; capsules of 0.003 g (3 mg) (N. 10, 50).