Medication Description: Budesonide (Budesonidum)
Synonyms: Apulein, Benacort, Budesonide, Budenofalk, Goracourt, Pulmicort, Rinocort, Cycortide Cycloclops, Apulein, Budenofalk, Budesonide, Cycortid Cyclocaps, Goracort, Pulmicort, Rhinocort.
White or off-white powder. Practically insoluble in water and heptane, moderately soluble in ethanol, good in chloroform.
Glucocorticosteroid preparation, similar in structure to triamcinolone acetonide, but characterized by the absence of a fluorine atom in the molecule (and the replacement of methyl radicals in the acetonide group by hydrogen and propyl).
Due to its low absorbability, it does not have a pronounced systemic effect, is better tolerated and does not cause significant atrophic changes in the skin with prolonged use compared with fluorinated preparations.
When inhaled, about 25% of the dose falls into the alveoli, C max is 15-45 min, T Ѕ - 2.8 h; excreted mainly by the kidneys.
Apply mainly locally: in the form of an ointment (cream) - with atopic dermatitis, psoriasis, eczema and in the form of inhalations - with bronchial asthma and obstructive bronchitis. In the form of capsules for oral administration (Budenofalk) proposed (as an anti-inflammatory agent) for Crohn's disease.
Inhalation adults are prescribed at the beginning (with exacerbation of bronchial asthma) 0.2-1.6 mg per day (in several doses), in less severe cases, 0.2-0.8 mg per day; children over 7 years old - at 0.2-0.8 mg per day in 2-4 doses). Rinse the throat thoroughly after inhalation.
The ointment is applied to the affected skin at first 2 times and then 1 time per day.
Inside prescribed in the form of capsules (without chewing, before meals), 0.003 g (3 mg) 3 times a day.
Possible side effects: when applied topically, hemorrhage, skin atrophy, dermatitis, folliculitis, hyperpigmentation, burning sensation, itching; with inhalation - dysphonia, cough, sore throat.
The drug is contraindicated in pregnancy and breastfeeding; for inhalations - for tuberculosis, fungal infection of the respiratory system; for local use - for infections of the skin, lichen; for oral administration - for gastrointestinal infections, severe violations of the liver.
Forms of release: powder for inhalation (0.1 and 0.2 mg / dose; 100 and 200 doses) complete with an inhaler (cyclo- or turbuhaler) and in capsules (0.2 mg / dose; 100 and 200 doses); 0,0125%; 0.025% and 0.05% suspension for inhalation in 2 ml containers (N. 4, 20); metered-dose aerosol for inhalation in cans of 10 ml (0.05 mg / dose — Budesonide-mitite and 0.2 mg / dose — Budesonide-forte; 200 doses); 0,025% ointment and cream in tubes of 15 g; capsules of 0.003 g (3 mg) (N. 10, 50).