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Description medicines: glimepiride (Glimepiride)

Glimepiride (Glimepiride).

1 - [[para- [2- (3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido) ethyl] phenyl] sulfonyl] -3- (trans-4-methyl-cyclohexyl) urea.

Synonym: Amaryl, Amaryl.

White or off-white crystalline powder. Practically insoluble in water.

Relatively new (early 1990s). Hypoglycemic drug group sulfonylureas.

In action similar to other sulfonylurea derivative used in the treatment of type II diabetes (non-insulin).

It has a relatively high activity and good tolerability.

Absorbed completely with max of 2-3 h, T ½ - 5-8 hours; biotransformation in the liver, kidneys predominantly displayed.

Assign, starting with a dose of 0,001 grams (1 mg), 1 per day (before breakfast, drinking water). If necessary increase dose to 1 mg every 1-2 weeks to 6 mg (in some cases up to 8 mg). The dose is set based on the control of blood sugar and urine.

Possible side effects: headache, dizziness, transient visual disturbances, dyspepsia, intracellular cholestasis, hypoglycemia, allergic reactions, etc.

Contraindications are basically the same as that of glibenclamide and other drugs of sulfonylureas.

Product: pills to 0,001; 0.002; 0.003; 0.004 and 0.006 g (1; 2; 3; 4 and 6 mg) (N. 15, 30, 120).