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Description of the medicine: Goserelin (Goserelin)

GOSERELIN (Goserelin).

Synonym: Zoladex, Zoladex.

Synthetic decapeptide is an analogue of the gonadotropin releasing factor (C 59 H 84 N 18 O 14 ).

By action, it is close to buserelin (see).

With max is 1.5-3 hours (a high level is maintained for 12-15 days in men and 22 days in women), T Ѕ - 2.5-4 hours.

Used for hormone-dependent prostate and breast cancer, endometriosis, uterine fibroids.

It is produced in the form of a special depot apparatus - a rod (capsule) of a cylindrical shape containing 3.6 or 10.8 mg of goserelin acetate, which is included in a biodegradable polymer matrix. The rod is in a special syringe. The drug is injected into the subcutaneous tissue of the anterior abdominal wall: 3.6 mg once every 28 days; 10.8 mg once every 3 months. In the treatment of prostate cancer, it is used in combination with antiandrogen drugs.

Duration of treatment is up to 6 months.

Possible side effects: in men - violation of the patency of the ureters; in women - hot flashes, fluctuations in blood pressure, menstrual irregularities, skin allergic reactions.

The drug is contraindicated in pregnancy and lactation.