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Medication Description: Goserelin (Goserelin)

GOZERELIN (Goserelin).

Synonym: Zoladex, Zoladex.

Synthetic decapeptide is an analogue of gonadotropin-releasing factor (C 59 H 84 N 18 O 14 ).

By action close to buserelin (see).

With max it is 1.5-3 hours (a high level is maintained for 12-15 days for men and 22 days for women), T Ѕ - 2.5-4 hours.

Applied with hormone-dependent cancer of the prostate and mammary gland, endometriosis, uterine fibroids.

Available in the form of a special depot-apparatus - a rod (capsule) of a cylindrical shape, containing 3.6 or 10.8 mg of goserelin acetate, included in a polymeric biodegradable matrix. The rod is in a special syringe. The drug is injected into the subcutaneous tissue of the anterior abdominal wall: 3.6 mg 1 time in 28 days; 10.8 mg 1 time in 3 months. In the treatment of prostate cancer used in combination with antiandrogenic drugs.

Duration of treatment up to 6 months.

Possible side effects: in men - a violation of the patency of the ureters; in women, hot flashes, fluctuations in blood pressure, menstrual disorders, skin allergic reactions.

The drug is contraindicated in pregnancy and lactation.