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Description medications: Goserelin (Goserelin)
Goserelin (Goserelin).
Synonym: Zoladex, Zoladex.
Synthetic decapeptide - analogue of gonadotropin releasing factor (C 59 H 84 N 18 O 14).
As of close to buserelin (cm.).
C max is 1.5-3 h (high level is maintained for 12-15 days in men and women 22 days), and T ½ - 2.5-4 hours.
Apply with hormone-prostate and breast cancer, endometriosis, uterine fibroids.
Available in a special depot apparatus - the rod (capsules) of cylindrical shape, containing 3.6 or 10.8 mg goserelin acetate incorporated in a biodegradable polymer matrix. The rod is in a special syringe. The drug is injected into the subcutaneous tissue of the abdominal wall: 3.6 mg 1 time in 28 days; 10.8 mg 1 time in 3 months. In the treatment of prostate cancer is used in conjunction with anti-androgenic agents.
The duration of treatment up to 6 months.
Possible side effects: men - violation of ureteral patency; women - hot flashes, blood pressure fluctuations, menstrual disorders, allergic skin reactions.
The drug is contraindicated during pregnancy and lactation.
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