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Description of the medicine: Dorzolamide (Dorzolamide)

DORZOLAMIDE (Dorzolamide).

4- (Ethylamino) -5,6-dihydro-6-methyl-4-H-thieno [2,3-b] thiopyran-2-sulfonamide-7,7-dioxide (hydrochloride).

Synonym: Trusopt, Trusopt.

White or off-white crystalline powder. Soluble in water, sparingly soluble in methanol and ethanol.

The chemical structure has elements of similarity with diacarb and hydrochlorothiazide.

It has a pronounced ability to block carbonic anhydrase in the ciliary body of the eye and effectively reduces intraocular pressure (mainly by reducing the secretion of aqueous humor) in patients with glaucoma when applied topically in the form of eye drops.

Assign with open-angle glaucoma of various types. The degree of reduction in intraocular pressure is usually not inferior to β-adrenergic blockers (timolol, betaxolol). It is tolerated better than pilocarpine (does not cause myosis).

Enter one drop into the conjunctival sac of a sick eye 2-3 times a day. The maximum hypotensive effect develops 2 hours after instillation and persists for 12 hours.

Perhaps the use of trisopt in combination with eye drops of β-blockers (timolol); sometimes there is an increase in the reduction of intraocular pressure.

When combined with several local ophthalmic preparations, each of them is administered with an interval of 10 minutes.

Trisopt drops (like other anti-glaucomatous eye drops) should be used under the systematic control of intraocular pressure. It is necessary to take into account the possibility of an individual reaction (in terms of effectiveness and tolerability).

When using drops of a trusopt, itching, burning and tingling in the eye, short-term blurred vision, bitterness in the mouth, in some cases conjunctivitis, blepharitis, allergic reactions (skin rash), paresthesia are possible.

The drug is contraindicated in severe renal failure, hypochloremic acidosis, pregnancy, breast-feeding, in childhood.

As in the case of the use of other drugs, cancel with increased individual sensitivity.

Release form: 2% solution in 5 ml dropper bottles.

Cosopt Eye drops containing 2% dorzolamide solution and 0.5% timolol solution (in 5 ml vials).