Medication Description: Butorphanol (Butorphanolum)
BUTORFANOL (Butorphanolum) * (-) -17- (Cyclobutylmethyl) -morphinan-3, 14-diol.
Synonyms: Moradol, Moradol, Stadol, Torate, Torbugesic, Torgesic, Torbutrol, Verstadol.
Butorphanol is a powerful analgesic for parenteral use. It belongs to the group of opiate receptor antagonist agonists and is close in this respect to pentazocine and nalbuphine. In terms of its strength, speed of onset of effect and duration of action, it is close to morphine, but is effective in smaller doses than morphine; a dose of butorphanol 2 mg causes strong analgesia. Compared with morphine, it has a low narcotic potential, less ability to cause physical dependence.
Butorphanol is used mainly for severe pains: in the postoperative period, in cancer patients, in renal colic, severe injuries, etc.
Enter intramuscularly or intravenously. The usual single dose for adults intramuscularly is 2 mg every 4 hours (1 to 4 mg, depending on the intensity of the pain). The usual single dose intravenously is 1 mg (0.5 to 2 mg) every 3 to 4 hours.
In anesthesia practice is used for sedation, during surgery and in the postoperative period. For the purpose of sedation is administered intramuscularly at a dose of 2 mg 30 - 60 minutes before surgery. During the operation, they are administered intravenously at a dose of 2-4 mg, if necessary, an additional 2 mg with a total dose of 4-12 mg 5 kg (0.06-0.18 mg / kg). You can use butorphanol in smaller doses (1 to 2 mg) in the composition of << lytic mixtures >> - in combination with diprazine, atropine.
In cancer patients, intramuscular injection in a single dose of 1 to 2 mg and a daily dose of 2 to 24 mg.
When using butorphanol, respiratory depression is about the same as when taking morphine (in equivalent doses), drowsiness, dizziness, weakness, sweating, nausea. There is an increase in pressure in the pulmonary artery and systolic blood pressure, increased heart rate, increased intracranial pressure. The occurrence of urticaria is possible.
Butorphanol should be used with great caution in respiratory failure, traumatic brain injury, impaired liver and kidney function. Caution should be exercised in patients with high blood pressure.
Do not prescribe the drug to patients under the age of 18 (due to the lack of sufficient experience in studying the effect of the drug in children and adolescents).
It should not be prescribed to patients with physical dependence on drugs.
Product form: in 1 ml ampoules containing 0.002 g (2 mg) of butorphanol tartrate, each in a package of 50 pieces.
Storage: taking into account the rules of storage of narcotic analgesics.