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Description of the medicine: Clopidogrel (Clopidogrel)

Clopidogrel.

Methyl - (+) - (S) -α- (ortho-chlorophenyl) -6,7-dihydro-thieno [3,2-c] pyridine-5 (4H) acetate.

Synonym: Plavix, Plavix.

The structure is close to ticlopidine.

Inhibits platelet aggregation by blocking (irreversibly) binding of adenosine diphosphate to platelet receptors.

Quickly absorbed in the digestive tract, C max is 1 h, T S - 8 h; Undergoes biotransformation in the liver with the formation of an active metabolite, is excreted in urine and feces.

Applied for the prevention of thrombosis in patients with IHD (after myocardial infarction), with atherosclerosis of the brain and peripheral vessels.

According to published foreign data, in patients with atherosclerosis clopidogrel exceeded acetylsalicylic acid in preventing cardiovascular complications (including deaths, strokes and myocardial infarction).

Assign inside adults to 0.075 g (1 tablet) 1 time per day (regardless of time of food intake).

The antiaggregation effect reaches a maximum after 4-7 days after the start of treatment and lasts 4-10 days.

Possible side effects, precautions and contraindications are the same as those of ticlopidine.

Compared with ticlopidine, the use of clopidogrel is associated with a lower risk of complications (primarily toxic effects on the bone marrow).

Children and adolescents (under 18 years) are not appointed (due to the lack of sufficient observations).

Form release: tablets of 0.075 g (75 mg) (N. 14, 28).