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Medication Description: Levothyroxin sodium (Levothyroxine sodium)

SODIUM LEVOTIRAXIN (Levothyroxine sodium).

O- (4-Oxy-3,5-diiodophenyl) -3,5-diyod-α-tyrosine sodium.

Synonyms: L-Tyrok, L-Thyroxin, Tyro-4, Eutirox, Eutirox, L-Thyrok, L-Thyroxin, Thyro-4.

Sodium salt of levorotatory isomer thyroxine.

In small doses it has an anabolic effect, in medium doses it stimulates the growth of the body, tissue demand for oxygen and the functional activity of the cardiovascular system and the central nervous system, and in large doses it inhibits the production of thyrotropin-releasing factor and thyroid stimulating hormone.

Relatively well absorbed (80%) in the small intestine, C max is about 6 hours, T Ѕ - 8 days; undergoes biotransformation (mainly in the liver, muscles and brain) with the formation of triiodothyronine.

Applied with hypothyroid conditions, euthyroid goiter, autoimmune thyroiditis, thyrotoxicosis, with carcinomas of the thyroid gland, as well as for the prevention of relapse of goiter after thyroid resection.

Assign inside (on an empty stomach in the morning, drinking water): for hypothyroidism - starting with a dose of 0.0125-0.05 mg (12.5-50 μg) per day with its gradual increase (every 2-3 weeks by 0.025-0.05 mg) to maintenance - 0.125-0.25 mg per day; after surgery for a thyroid tumor - up to 0.3 mg per day; in the treatment of hyperthyroidism - by 0.005-0.1 mg per day; with euthyroid goiter and for the prevention of its recurrence after resection in adults - by 0.075-0.2 mg, for children - by 0.0125-0.15 mg per day.

Possible side effects: tachycardia, arrhythmias, chest pain, tremor, anxiety, insomnia, hyperhidrosis, diarrhea, alopecia, dysfunction of the adrenal glands.

The drug is contraindicated in case of hypersensitivity to iodine, ischemic heart disease, tachyarrhythmias, heart failure, severe arterial hypertension, impaired function of the adrenal cortex.

Form release: pills to 0.025; 0.05; 0.1 and 0.15 mg (N. 25, 50).