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Description of the medicine: Levothyraxine sodium (Levothyroxine sodium)

Levothyraxine Sodium (Levothyroxine sodium).

O- (4-hydroxy-3,5-diiodophenyl) -3,5-diiodo-α-tyrosine sodium.

Synonyms: L-Tyrok, L-Thyroxine, Tyro-4, Eutiroks, Eutirox, L-Thyrok, L-Thyroxin, Thyro-4.

The sodium salt of the levorotatory isomer of thyroxine.

In small doses it has an anabolic effect, in medium doses it stimulates the growth of the body, oxygen demand of the tissues and the functional activity of the cardiovascular system and central nervous system, in large doses it inhibits the production of thyrotropin releasing factor and thyroid stimulating hormone.

Relatively well absorbed (80%) in the small intestine, C max is about 6 hours, T Ѕ - 8 days; undergoes biotransformation (mainly in the liver, muscles and brain) with the formation of triiodothyronine.

It is used for hypothyroid states, euthyroid goiter, autoimmune thyroiditis, thyrotoxicosis, for thyroid carcinomas, as well as for the prevention of goiter recurrence after thyroid resection.

Assign inside (on an empty stomach in the morning, washed down with water): for hypothyroidism - starting from a dose of 0.0125-0.05 mg (12.5-50 μg) per day with a gradual increase (every 2-3 weeks by 0.025-0.05 mg) to maintenance - 0.125-0.25 mg per day; after surgery for a thyroid tumor - up to 0.3 mg per day; in the complex treatment of hyperthyroidism - 0.005-0.1 mg per day; with euthyroid goiter and for the prevention of its relapse after resection in adults - 0.075-0.2 mg, for children - 0.0125-0.15 mg per day.

Possible side effects: tachycardia, arrhythmias, chest pains, tremors, anxiety, insomnia, hyperhidrosis, diarrhea, alopecia, adrenal gland dysfunction.

The drug is contraindicated in case of hypersensitivity to iodine, ischemic heart disease, tachyarrhythmias, heart failure, severe arterial hypertension, impaired adrenal cortex function.

Release form: tablets on 0,025; 0.05; 0.1 and 0.15 mg (N. 25, 50).