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Description drugs: sodium Levotiraksin (Levothyroxine sodium)

LEVOTIRAKSIN Sodium (Levothyroxine sodium).

O- (4-Hydroxy-3,5-diyodfenil) -3,5-diiodo-α-tyrosine sodium.

Synonyms: L-Tirok, L-thyroxine, Tiro-4 Eutiroks, Eutirox, L-Thyrok, L -Thyroxin, Thyro- 4.

The sodium salt of the levorotatory isomer of thyroxine.

At low doses, it has an anabolic effect in the medium - stimulates the growth of the organism, tissue oxygen demand and functional activity of the cardiovascular system and central nervous system, in high - inhibits the production of thyrotropin-releasing hormone and thyrotropin.

Relatively well absorbed (80%) in the small intestine, C max is about 6 h, T S - 8 days; Biotransformation (primarily in the liver, muscle, and brain) to form triiodothyronine.

Apply in hypothyroid states, euthyroid goitre, autoimmune thyroiditis, hyperthyroidism, when the thyroid carcinomas, as well as for the prevention of goiter recurrence after resection of the thyroid gland.

Assign inside (in the morning on an empty stomach, with water): hypothyroidism - starting with a dose 0,0125-0,05 mg (12.5-50 mg) per day with a gradual increase in its (every 2-3 weeks at 0.025-0.05 mg) to maintenance - 0.125-0.25 mg per day; after surgery for thyroid tumor - 0.3 mg per day; in the treatment of hyperthyroidism - at 0.005-0.1 mg per day; with euthyroid goitre and prevention of its recurrence after resection in adults - on 0,075-0,2 mg, children - 0,0125-0,15 mg per day.

Possible side effects: tachycardia, arrhythmia, chest pain, tremor, anxiety, insomnia, rash, diarrhea, alopecia, disturbances of adrenal function.

The drug is contraindicated in case of hypersensitivity to iodine, ischemic heart disease, tachyarrhythmias, congestive heart failure, severe hypertension, disturbance of function of the adrenal cortex.

Product: pills to 0,025; 0.05; 0.1 and 0.15 mg (N. 25, 50).