Medication Description: Linestrenol (Lynestrenol)
Synonyms: Orgametril, Exluton, Exluton, Orgametril.
It has a gestastinal and weak androgenic effect.
Quickly and completely absorbed in the digestive tract, C max is 2 h; undergoes biotransformation in the liver with the formation of the active metabolite of norethisterone (see), excreted mainly by the kidneys.
Applied with dysfunctional uterine bleeding, amenorrhea and oligomenorrhea, endometriosis, mastopathy, premenstrual syndrome, endometrial carcinoma.
Assign inside: with endometriosis and dysfunctional uterine bleeding - 0.005-0.015 g (5-15 mg) per day for at least 6 months; with amenorrhea (after preparation with estrogens) - from 0.005 to 0.01 g (5-10 mg) per day in the second half of the cycle; with premenstrual syndrome - 0.005 g (5 mg) per day from the 14th to the 25th day of the cycle; for contraception - 0.0005 g (0.5 mg) per day; in case of carcinoma of the endometrium, by 0.03-0.05 g (30-50 mg) per day.
Possible side effects: nausea, diarrhea, depression, nervousness, weight gain, acne, pruritus.
The drug is contraindicated in severe violations of the liver, uterine bleeding of unknown etiology, otosclerosis, arterial hypertension, heart failure, depression, thromboembolic complications, insulin-dependent diabetes mellitus (decreases glucose tolerance).
Product form: tablets of 0.0005 and 0.005 g (0.5 and 5 mg) (N. 28 and 30, respectively).
Storage: List B.