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Description of the medicine: Linestrenol (Lynestrenol)

LINESTRENOL (Lynestrenol).

(17α) -19-Norpregn-4-en-20-yn-17-ol.

Synonyms: Orgametril, Exluton, Exluton, Orgametril.

It has a gestational and weak androgenic effect.

Quickly and completely absorbed in the digestive tract, C max is 2 hours; undergoes biotransformation in the liver with the formation of the active metabolite of norethisterone (see), excreted mainly by the kidneys.

It is used for dysfunctional uterine bleeding, amenorrhea and oligomenorrhea, endometriosis, mastopathy, premenstrual syndrome, endometrial carcinoma.

Assign inside: with endometriosis and dysfunctional uterine bleeding - 0.005-0.015 g (5-15 mg) per day for at least 6 months; with amenorrhea (after preparation with estrogen) - 0.005-0.01 g (5-10 mg) per day in the second half of the cycle; with premenstrual syndrome - 0.005 g (5 mg) per day from the 14th to the 25th day of the cycle; for contraception - 0.0005 g (0.5 mg) per day; with endometrial carcinoma - 0.03-0.05 g (30-50 mg) per day.

Possible side effects: nausea, diarrhea, depression, nervousness, weight gain, acne, itchy skin.

The drug is contraindicated in severe hepatic impairment, uterine bleeding of unknown etiology, otosclerosis, arterial hypertension, heart failure, depression, thromboembolic complications, insulin-dependent diabetes mellitus (reduces glucose tolerance).

Release form: tablets on 0,0005 and 0,005 g (0,5 and 5 mg) (N. 28 and 30 respectively).

Storage: List B.