Before taking the course, consult a doctor!
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Description of the medicine: Repaglinide (Repaglinide)
Repaglinide.
(+) - 2-Ethoxy-α - [[(S) -α-isobutyl-ortho-piperidino-benzyl] -carbamoyl] -para-toluic acid.
Synonym: NovoNorm, NovoNorm.
By blocking the ATP-dependent potassium channels of the pancreatic β-cells, it causes their depolarization, which leads to the opening of calcium channels and, as a result, an increase in the secretion of insulin.
Quickly and completely absorbed in the digestive tract, bioavailability is about 56%, C max - 1 h, T S - 1 h; Is subjected to intensive biotransformation in the liver, is excreted mainly with bile.
Apply for diabetes mellitus type II.
Assign inside (before meals), starting with 0.0005 g (0.5 mg) 3 times a day, increasing the dose depending on the glycemia no earlier than 1-2 weeks. The maximum single and daily doses are 0.004 and 0.016 g (4 and 16 mg), respectively. Can be combined with metformin.
Possible side effects: hypoglycemic reactions, dyspepsia, visual acuity.
The drug is contraindicated in diabetic coma, expressed violations of the liver and kidneys, pregnancy and lactation.
Product: tablets of 0.0005; 0.001 and 0.002 g (0.5, 1 and 2 mg) (N. 15, 30).
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