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Description of the medicine: Triptorelin (Triptorelin)

TRIPTORELIN (Triptorelin).

Synonyms: Decapeptyl, Diferelin, Decapeptyl, Diphereline.

A synthetic analogue of gonadotropin releasing factor.

It differs from natural hormone in a lower rate of biotransformation and slower excretion from the body.

Available in the form of acetate (C 64 H 82 N 18 O 13 · C 2 H 4 O 2 ).

By action, it is close to buserelin (see).

With intramuscular and subcutaneous administration, the bioavailability is approximately 39% and 69%, respectively, T Ѕ - 7.6 hours

It is used for endometriosis, uterine myoma, progressive ovarian carcinoma, hormone-dependent prostate cancer, and extracorporeal procedures.

Assign subcutaneously or intramuscularly.

Subcutaneously (mainly in the treatment of infertility) is administered 0.5 mg once a day for 7 days, then 0.1 mg per day. When using the depot form (Diferelin depot), 3.75 mg is administered intramuscularly once every 4 weeks for up to 6 months.

Possible side effects: weakening libido, gynecomastia, decreased bone mineralization, sleep disturbances, mood swings, depression, visual impairment, myalgia, increased blood pressure, local allergic reactions, etc.

The drug is contraindicated for polycystic ovaries, hormone-independent prostate cancer, osteoporosis, pregnancy and lactation.

Method of release: 0.01% and 0.05% solutions for injection in disposable syringe ampoules of 1 ml; powder for suspension for subcutaneous administration in vials of 0.1 mg and for suspension of prolonged release for intramuscular administration in vials and microcapsules (disposable syringes) of 3.75 mg complete with a solvent.