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Description medications: triptorelin (Triptorelin)

Triptorelin (Triptorelin).

Synonyms: Dekapeptil, Diferelin, Decapeptyl, Diphereline.

The synthetic analogue of gonadotropin-releasing factor.

It differs from the natural hormone at a rate of biotransformation and the slower release from the body.

Available in the form of acetate (C 64 H 82 N 18 O 13 · C 2 H 4 O 2).

As of close to buserelin (cm.).

For intramuscular and subcutaneous bioavailability of respectively about 39% and 69%, T S - 7.6 hours.

Apply with endometriosis, uterine myoma, advanced ovarian carcinoma, hormone-prostate cancer during extracorporeal procedures.

Assign subcutaneously or intramuscularly.

Subcutaneous (mainly in the treatment of infertility) administered with 0.5 mg 1 time per day for 7 days, followed by 0.1 mg a day. When using the depot formulation (Diferelin depot) is administered by intramuscular injection of 3.75 mg 1 every 4 weeks for up to 6 months.

Possible side effects: weakening of libido, gynecomastia, decreased bone mineralization, sleep disturbances, mood swings, depression, blurred vision, myalgia, increased blood pressure, local allergic reactions and others.

The drug is contraindicated in polycystic ovaries, hormone-independent prostate cancer, osteoporosis, pregnancy and breastfeeding.

issuance: 0.01% and 0.05% solutions for injection in single-use syringe of 1 ml ampoules; powder for suspension for subcutaneous injection in vials of 0.1 mg and sustained release suspension for intramuscular injection in vials and microcapsules (disposable syringes) 3.75 mg together with the solvent.