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Medication description: Alendronat sodium (Alendronat sodium)

SODIUM ALDRONAT (Alendronat sodium).

Sodium salt of (4-amino-1-hydroxybutylidene) -diphosphonic acid.

Synonym: Fosamax, Fosamax.

White crystalline powder. Soluble in water, slightly soluble in alcohol.

It has the ability to bind hydroxyapatite contained in bones and inhibit the activity of osteoclasts performing bone resorption.

When introduced into the body, the drug accumulates in significant quantities in the bone tissue.

When ingestion is absorbed about 25% of the dose, bioavailability is only 0.6-0.8%, T Ѕ - up to 10 hours.

Applied for the treatment of osteoporosis, especially in women during menopause, as well as with Paget's disease (deforming osteitis).

Is taken orally at 0.01 g (10 mg) 1 time per day half an hour before meals (or earlier). Wash down with a glass of usual, but not mineral water. Additionally prescribed inside calcium preparations at the rate of 0.5 g of calcium per day. The treatment is carried out for a long time (for years). After 3 years, the dose of sodium alendronate (fosamax) is reduced to 0.005 g (5 mg) per day.

When Paget's disease is prescribed, 0.04 g per day for 6 months.

In the process of treatment, there is an increase in bone mineral density and a decrease in the frequency of their new fractures.

When using the drug may cause disorders of the gastrointestinal tract (constipation or diarrhea, flatulence, pain in the stomach, esophagitis), allergic reactions (skin rash, erythema), headache.

Contraindicated in hypocalcemia, severe renal failure.

Calcium preparations and products containing it should be taken no earlier than 1-2 hours after taking alendronate, as it delays absorption of alendronate (and other bisphosphonates) from the intestine.

Product form: tablets of 0.01 g (10 mg) (N. 28).