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Description of the medicine: Alendronat sodium (Alendronat sodium)

SODIUM ALENDRONATE (Alendronat sodium).

Sodium salt of (4-amino-1-hydroxybutylidene) diphosphonic acid.

Synonym: Fosamax, Fosamax.

White crystalline powder. Soluble in water, slightly soluble in alcohol.

It has the ability to bind hydroxyapatite contained in the bones and inhibit the activity of osteoclasts performing bone resorption.

When introduced into the body, the drug accumulates in a significant amount in the bone tissue.

When taken orally, about 25% of the dose is absorbed, bioavailability is only 0.6-0.8%, T до - up to 10 hours.

It is used to treat osteoporosis, especially in women during menopause, as well as with Paget's disease (deforming osteitis).

It is taken orally at 0.01 g (10 mg) once a day half an hour before meals (or earlier). Wash down with a glass of ordinary, but not mineral water. Additionally, calcium preparations are prescribed inside at the rate of 0.5 g of calcium per day. Treatment is carried out for a long time (for years). After 3 years, the dose of sodium alendronate (fosamax) is reduced to 0.005 g (5 mg) per day.

In case of Paget's disease, 0.04 g per day is prescribed for 6 months.

During treatment, an increase in bone mineral density and a decrease in the frequency of their new fractures are noted.

When using the drug, gastrointestinal disorders are possible (constipation or diarrhea, flatulence, pain in the stomach, esophagitis), allergic reactions (skin rash, erythema), headache.

Contraindicated in hypocalcemia, severe renal failure.

Calcium preparations and products containing it should be taken no earlier than 1-2 hours after taking alendronate, as it delays the absorption of alendronate (and other bisphosphonates) from the intestine.

Release form: tablets on 0,01 g (10 mg) (N. 28).