Description of the medicine: Acitretin (Acitretin)
9- (4-Methoxy-2,3,6-trimethylphenyl) -3,7-dimethyl-2,4,6,8-nonatetraenoic acid.
Synonym: Neotigazone, Neotigason.
The chemical structure of acitretin (neotigazone) differs from tigazone in that it is the acid corresponding to tigazone, and tigazone is its ethyl ether (that is, it contains the COOC 2 H 5 group in the side chain instead of the COOH radical).
According to the action, acitretin is close to tigazone, but it is slightly better tolerated, although it has side effects to one degree or another, as well as teratogenic activity.
Quickly and completely absorbed in the digestive tract, bioavailability is 60%, C max -1-4 hours, T Ѕ - 50 hours; undergoes biotransformation in the liver (in some cases, etretinate is formed), excreted in urine and bile for 1 month to 2 years.
Used in severe forms of psoriasis, congenital ichthyosis, lichen (red, hairy, flat, pityriasis), Darier’s disease.
The action of the drug is associated with the ability to normalize the processes of renewal, differentiation and keratinization of skin cells.
Assign inside (with food): adults at 0.025-0.03 g (25-30 mg) once a day, after 2-4 weeks it is possible to increase the daily dose to 0.075 g (75 mg); children - 0.5 mg / kg per day (if necessary, up to 1 mg / kg per day, but not more than 35 mg per day).
When using the drug, the occurrence of hypervitaminosis A is possible (dry skin and mucous membranes, peeling of the skin, brittle nails, hair loss, hyperlipidemia, hypercalcemia, etc.).
Contraindicated in pregnancy (danger of teratogenic effects), with severe violations of the liver and kidneys, severe cardiovascular diseases.
You should not use the drug with retinol (vitamin A), tetracycline antibiotics, methotrexate, and other drugs that disrupt the liver and kidneys.
Release form: capsules of 0.01 and 0.025 g (10 and 25 mg) (N. 50, 100).