Medication Description: Acitretin (Acitretin)
9- (4-Methoxy-2,3,6-trimethylphenyl) -3,7-dimethyl-2,4,6,8-nonatetraenoic acid.
Synonym: Neotigazon, Neotigason.
According to the chemical structure, acitretin (neotigazone) differs from tigazon in that it is an acid corresponding to tigazon, and tigazon differs from its ethyl ether (that is, it contains in the side chain, instead of the COOH radical, the COOC group 2H 5 ).
The effect of acitretin is close to tigazon, but is somewhat better tolerated, although in one degree or another it has side effects and teratogenic activity.
Quickly and completely absorbed in the digestive tract, bioavailability is 60%, C max -1-4 h, T - 50 h; undergoes biotransformation in the liver (in some cases, etretinate is formed), is excreted in the urine and bile for 1 month to 2 years.
Applied with severe forms of psoriasis, congenital ichthyosis, herpes (red, hairy, flat, scaly), Darya disease.
The action of the drug is associated with the ability to normalize the processes of renewal, differentiation and keratinization of skin cells.
Assign inside (during meals): adults to 0,025-0,03 g (25-30 mg) 1 time per day, after 2-4 weeks you can increase the daily dose to 0.075 g (75 mg); for children - 0.5 mg / kg per day (if necessary up to 1 mg / kg per day, but not more than 35 mg per day).
The use of the drug is likely to cause hypervitaminosis A (dry skin and mucous membranes, peeling of the skin, brittle nails, hair loss, hyperlipidemia, hypercalcemia, etc.).
Contraindicated in pregnancy (danger of teratogenic action), with pronounced violations of the functions of the liver and kidneys, severe cardiovascular diseases.
Do not use the drug with retinol (vitamin A), tetracycline antibiotics, methotrexate, other drugs that violate the functions of the liver and kidneys.
Product form: capsules of 0.01 and 0.025 g (10 and 25 mg) (N. 50, 100).