Description of the medicine: Dexfenfluramine (Dexfenfluramine)
(+) N-Ethyl-α-methyl-m- (trifluoromethyl) phenethylamine.
Synonym: Isolipan, Izolipan.
Produced in the form of hydrochloride.
In structure it is similar to sympathomimetic amines (including phenamine), but it has little central stimulating activity, it also has a strong anorexigenic effect.
Activates serotonergic transmission in the ventromedial nuclei of the hypothalamus ("saturation center").
Quickly and completely absorbed in the digestive tract, bioavailability is about 70%, C max - 4 h, T S - 20 h; Is biotransformation in the liver, excreted by the kidneys.
Used mainly for alimentary obesity, as well as for other conditions requiring a decrease in body weight.
Assign 0.015 g (1 capsule) 2 times a day (morning and evening) with meals in combination with a low-calorie diet. The course of treatment lasts usually 3 months. Body weight can decrease by 7-10 kg (with individual fluctuations) during this time. Treatment should be conducted under medical supervision.
Possible side effects and contraindications are basically the same as with other drugs of this group (see Fepranon).
Form release: capsules of 0.015 g (15 mg).
Storage: List A. It is only available on prescription.