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Description of the medicine: Dexfenfluramine (Dexfenfluramine)

DEXFENFLURAMINE (Dexfenfluramine).

(+) N-Ethyl-α-methyl-m- (trifluoromethyl) phenethylamine.

Synonym: Isolipan, Izolipan.

Available in the form of hydrochloride.

In structure, it is similar to sympathomimetic amines (including phenamine), but it has a slightly pronounced central stimulating activity, and at the same time has a strong anorexigenic effect.

It activates serotonergic transmission in the ventromedial nuclei of the hypothalamus (“center of saturation”).

Quickly and completely absorbed in the digestive tract, bioavailability is about 70%, C max - 4 hours, T Ѕ - 20 hours; undergoes biotransformation in the liver, excreted by the kidneys.

It is used mainly for alimentary obesity, as well as for other conditions requiring a decrease in body weight.

Assign 0.015 g (1 capsule) 2 times a day (morning and evening) with meals in combination with a low-calorie diet. The course of treatment usually lasts 3 months. Body weight may decrease by 7-10 kg (with individual fluctuations) during this time. Treatment should be carried out under medical supervision ..

Possible side effects and contraindications are basically the same as with other drugs in this group (see Fepranon).

Release form: capsules of 0.015 g (15 mg).

Storage: List A. It is released only by prescription.