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Description of the medicine: Latanoprost

Latanoprost.

[3,5-Dihydroxy-2 (3-hydroxy-5-phenyl-pentyl) cyclopentyl] -1-pentyl ester of heptanoic acid.

Synthetic eicosanoid group of prostaglandin F .

Of the pharmacological properties of latanoprost, its ability in low concentrations to cause a reduction in intraocular pressure (IOP) in patients with open-angle glaucoma and its production began to be produced abroad as eye drops for ophthalmic practice under the name "Xalatan". Under the same name, it is registered and used in the Russian Federation.

Xalatan - 0.005% aqueous solution of latanoprost with the addition of a stabilizer - sodium dihydrogen phosphate, antiseptic - benzalkonium chloride, sodium chloride. Colorless transparent liquid.

The drug reduces IOP by stimulating the outflow of intraocular moisture through the muscle fibers of the ciliated body into the suprachoroidal space and then outward through the sclera. Systemic arterial pressure and respiration have no significant effect.

Applied mainly with open-angle glaucoma, as well as ineffectiveness of other agents used to reduce intraocular pressure.

The drug penetrates well through the cornea. When instilled, the decrease in IOP is observed after 3-4 hours, reaches a maximum after 8-12 hours, and lasts up to 24 hours or more.

Instilled in xalatan 1 drop in the diseased eye 1 time per day (evening). It is noted that an increase in the number of drops does not increase, but decreases the effectiveness of the drug.

On the strength of hypotensive action against IOP, xalatan practically corresponds to the action of 0.5% solution (eye drops) of timolol and its analogues.

Usually the drug is well tolerated (miosis is not observed).

Possible side effects: a sensation of mild pain in the eye, conjunctival hyperemia, allergic reactions. A characteristic side effect is the intensification (after a relatively long application 3-4 months or more) of the pigmentation of the iris of the eye (in which the instillation was done) from blue to brown, sometimes leading to the heterochromia of the eye. Dark eyelashes can get eyelashes and skin around the eyes.

The drug is contraindicated in pregnancy and lactation.

Xalatan can be used in combination with other antiglaucomatous drugs.

Form release: 0,005% solution in vials of 2.5 ml (a smaller amount of the drug in one package compared to other hypotensive eye drops due to its relatively low stability). Apply xalatan after opening the bottle should not more than 4 weeks.