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Medication Description: Latanoprost (Latanoprost)

LATANOPROST (Latanoprost).

[3,5-Dioxy-2 (3-hydroxy-5-phenyl-pentyl) cyclopentyl] -1-pentyl ester of heptanoic acid.

Synthetic eicosanoid group of prostaglandin F .

Because of the pharmacological properties of latanoprost, special attention was drawn to its ability in low concentrations to cause a decrease in intraocular pressure (IOP) in patients with open-angle glaucoma and began to be produced abroad in the form of eye drops for ophthalmic practice called "Xalatan". Under the same name it is registered and applied in the Russian Federation.

Xalatan (Xalatan) - 0.005% aqueous solution of latanoprost with the addition of a stabilizer — sodium dihydrogen phosphate, an antiseptic — benzalkonium chloride, sodium chloride. Colorless clear liquid.

The drug reduces IOP by stimulating the outflow of intraocular moisture through the muscle fibers of the ciliary body to the suprachoroidal space and then out through the sclera. There is no significant effect on systemic arterial pressure and respiration.

Used mainly in open-angle glaucoma, as well as the ineffectiveness of other means used to reduce intraocular pressure.

The drug penetrates the cornea well. When instilled, a decrease in IOP is observed after 3-4 hours, reaches a maximum after 8-12 hours and persists up to 24 hours or more.

Instill ksalatan 1 drop in a sore eye 1 time per day (in the evening). It is noted that the increase in the number of drops does not increase, but reduces the effectiveness of the drug.

The strength of the hypotensive effect in relation to IOP xalatan practically corresponds to the action of a 0.5% solution (eye drops) of timolol and its analogues.

Usually the drug is well tolerated (miosis is not observed).

Possible side effects: a feeling of mild pain in the eye, conjunctival hyperemia, allergic reactions. A characteristic side effect is the enhancement (after a relatively long use of 3-4 months or more) of pigmentation of the iris (which was instilled) from blue to brown, sometimes leading to heterochromia of the eye. Dark color can get eyelashes and skin around the eyes.

The drug is contraindicated in pregnancy and lactation.

Xalatan can be used in combination with other antiglaucomatous agents.

Product form: 0.005% solution in 2.5 ml vials (a smaller amount of the drug in one package compared to other antihypertensive eye drops due to its relatively low stability). Apply Ksalatan after opening the bottle should be no more than 4 weeks.