Description of the medicine: Antipyrine (Antipyrinum)

ANTIPYRIN (Antipyrinum). 1-Phenyl-2, 3-dimethylpyrazolone-5.

Synonyms: Analgesin, Anodynin, Azophen, Methozin, Parodyne, Phenazonum, Phenazone, Phenylon, Pyrazoline, Pyrodin, Sedatin and others.

Colorless crystals or white crystalline powder odorless, slightly bitter taste. Very easily soluble in water (1: 1), easily - in alcohol. Solutions (pH 6, 0 - 7, 5) are sterilized at + 120 C for 20 min.

Antipyrine was one of the first synthetic analgesics, derivatives of pyrazolone, found use in medicine (1884). With the receipt of other analgesics, they began to be used relatively rarely. He does not currently have a wide application. However, he did not lose all the values ​​and remained in the nomenclature of medicines.

Like other pyrazolone derivatives, antipyrine has analgesic, antipyretic and to some extent anti-inflammatory effect. Analgesic and antipyretic activity of this group of drugs are close to derivatives of salicylic acid. The derivatives of pyrazolone reduce the permeability of capillaries and prevent the development of an inflammatory reaction. The mechanism of this action is not clear. Influences on the pituitary-adrenal system these compounds do not exert.

The most active anti-inflammatory drug of this group - butadione - relatively strongly inhibits the biosynthesis of prostaglandins. It is classified as a group of non-steroidal anti-inflammatory drugs.

Antipyrine has a moderate analgesic, antipyretic and anti-inflammatory effect. With local application, a certain hemostatic effect is noted.

Apply antipyrine for neuralgia, colds.

Give adults inside by 0.25-0.5 g; Children over 6 months of age - 0.025 - 0.15 g per reception, depending on the age. Take 2 - 3 times a day.

Higher doses for adults inside: single dose of 1 g, daily 3 g.

As a hemostatic agent, antipyrine is sometimes used (10 - 20% solution) to wet tampons and napkins in nasal and parenchymal hemorrhages.

When prescribing antipyrine, one should consider the possibility of hypersensitivity of patients to the drug with the appearance of hives and a fixed rash; Possibly oppression of hematopoiesis (see Amidopyrin).

Form release: powder and tablets of 0.25 g.

For use in children's practice, tablets of 0.05; 0.075; 0.1 and 0.15 g.

Storage: List B. In a well-ukuporennoy packaging, protecting from the effects of light.

Rr .: Tab. Antipyrini 0.25 N. 10

DS 1 tablet 2 to 3 times a day

Rp .: Sol. Antipyrini 10% 30 ml

DS For wetting tampons with nosebleeds

Tablets << Ankofen >> (Tabulettae << Ancophenum >>).

Ingredients: antipyrine and phenacetin 0.25 g, caffeine-benzoate sodium 0.05 g. Analgesic and antipyretic. Assign 1 tablet 1 - 2 - 3 times a day.

Storage: List B.