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Description of the medicine: Orlistat (Orlistat)

ORLISTAT (Orlistat).

Synonym: Xenical, Xenical.

A synthetic analogue of tetrahydrolipostatin produced by Streptomyces toxytricini.

By inhibiting gastric, pancreatic and intestinal lipases, it blocks the cleavage of triglycerides in the intestine, which leads to a decrease in absorption and free fatty acids and monoglycerides into the systemic circulation. Thus, the drug is fundamentally different from anorexigen - it does not affect appetite, but on the absorption of fats in the digestive tract.

After ingestion, it does not enter the systemic circulation, is excreted gradually (within 3-5 days) with feces, mainly unchanged.

The drug has both a hypocholesterolemic and hypotriglyceridemic effect, improves glucose tolerance.

Orlistat is prescribed on the background of a low-calorie diet (containing no more than 30% fat) at a dose of 0.12 g (1 capsule) 3 times a day - with each meal.

The drug is relatively well tolerated, but possible side effects sometimes make it difficult to use. In some cases, imperative urges to defecate, flatulence, oily discharge from the intestines, fecal incontinence, rarely arterial hypertension are likely.

The drug is contraindicated in chronic malabsorption, cholestasis, pregnancy, breastfeeding, in childhood.

Release form: capsules on 0,12 g (N. 21).