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Medication Description: Orlistat (Orlistat)

ORLISTAT (Orlistat).

Synonym: Xenical, Xenical.

Synthetic analogue of tetrahydrolipostatin produced by Streptomyces toxytricini.

Inhibiting gastric, pancreatic and intestinal lipases, blocks the splitting of triglycerides in the intestine, which leads to a decrease in the absorption and entry into the systemic circulation of free fatty acids and monoglycerides. Thus, the drug is fundamentally different from anorexigenes - it affects not the appetite, but the absorption of fat in the gastrointestinal tract.

After ingestion, it does not enter the systemic circulation, is gradually excreted (within 3-5 days) with feces, mostly unchanged.

The drug has simultaneously hypocholesterolemic and hypotriglyceridemic effect, improves glucose tolerance.

Orlistat is prescribed on the background of a low-calorie diet (containing no more than 30% fat) in a dose of 0.12 g (1 capsule) 3 times a day - with each meal.

The drug is relatively well tolerated, but possible side effects sometimes make it difficult to use. In some cases, imperative urges to defecate, flatulence, oily discharge from the intestines, fecal incontinence, rarely arterial hypertension are likely.

The drug is contraindicated in chronic malabsorption, cholestasis, pregnancy, breast-feeding, in childhood.

Form release: capsules to 0.12 g (N. 21).