Medication Description: Pamidronate sodium (Pamidronate disodium)
SODIUM PAMIDRONAT (Pamidronate disodium).
Disodium salt of (3-amino-1-hydroxypropylidene) -diphosphonic acid.
Synonym: Aredia, Aredia.
The chemical structure and mechanism of action is close to sodium alendronate.
Inhibits bone resorption.
T Ѕ is 27-28 hours; not biotransfected, excreted by the kidneys.
Prescribed mainly for osteoporosis (osteolysis) in patients with malignant tumors with bone metastases, as well as with "steroid" osteoporosis and Paget's disease.
It is noted that the use of the drug reduces bone pain and there are signs of repair in the foci of osteolysis.
Assign as a slow infusion (you can not enter the jet). The lyophilized powder is first diluted in water for injection (0.015 g is dissolved in 5 ml; 0.03 g in 10 ml), then an infusion solution is prepared. Dose set individually based on the initial concentration of calcium in the blood. For adults and elderly people with a calcium concentration in the blood below 3 mmol / l, the exchange rate dose is 0.015-0.03 g, with 3-3.5 mmol / l - 0.03-0.06 g, with 3.5- 4 mmol / l - 0.09 g. Maximum course dose - 0.09 g. The total dose is prescribed in the form of a single infusion (for 2 hours) or several infusions (within 2-4 days).
For Paget's disease, 0.03 g is administered as a 4-hour infusion over 3 days; course repetition is possible.
When using the drug is likely to develop moderate hypocalcemia, moderate hyperthermia, nausea, vomiting, bone pain, oppression of blood, allergic reactions, pain at the injection site.
Contraindicated in severe impaired renal function, pregnancy and breastfeeding.
Incompatible with calcium infusion solutions.
Product form: lyophilized powder for injection solutions in vials of 0.015; 0.03; 0.06 and 0.09 g (15, 30, 60 and 90 mg), complete with solvent.
Storage: at a temperature not higher than +30 ° С.