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Medication Description: Sargramostim

SARGRAMOSTIM (Sargramostim).

Synonyms: Leikin, Prokin, Leukine, Prokine.

A glycosylated polypeptide containing 127 amino acid residues. The molecular weight is 15 500-19 500 daltons. (C 639 H 1002 N 168 O 198 S 8 ).

Get genetically engineered through the yeast Saccharomyces cerevisiae.

Stimulates the formation of granulocytes, macrophages and eosinophils.

Injected intravenously (infusion - for 2 hours) or subcutaneously.

Doses set individually.

It is usually used (for neutropenia associated with chemotherapy of malignant tumors with cytostatic agents and for bone marrow transplantation) at the rate of 250 μg per 1 m 2 of body surface per day. If necessary, increase the dose to 500 µg / m 2 per day.

When using the drug, there may be a violation of vascular permeability, fluid retention in the body, difficulty breathing, general weakness, fever, thrombophlebitis, thrombosis.

Product form: powder for injection solutions in vials of 0.25 and 0.5 mg.

The contents of the vial are dissolved in 1 ml of sterile water for injection (without shaking, in order to avoid the formation of foam). For infusion then diluted in 0.9% sodium chloride solution.

Storage: at temperature from +2 to +8 ° С.