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Medication Description: Tretinoin (Tretinoin)

TRETINOIN (Tretinoin).

The trans form of retinoic acid (has the same structure as the cis form - see Isotretinoin).

Synonyms: Airol, Vesanoid, Lokatsid, Retin-A, Abarel, Acnavit, Acnelyse, Acretin, Airol, Aknoten, Aviderm, Dermairol, Effederm, Locacid, Retin-A, Tretin, Vesanoid, etc.

Yellow or light orange crystalline powder. Practically insoluble in water, glycerin and mineral oils; hardly soluble in ethanol, polyethylene glycol, dimethyl sulfoxide.

When applied topically, it is close to isotretinoin (roaccutane).

With the introduction of the inside stimulates the processes of differentiation and inhibits the proliferation of promyelocytes.

With dermal application up to 30% of the drug is absorbed. With the introduction of the inside is absorbed quickly, C max is 1-2 hours, T Ѕ - 30 min-2 h; Biotransformation in the liver, excreted in the urine and feces.

It is prescribed for acne vulgaris and drainage (local) and for acute promyelocytic leukemia resistant to standard chemotherapy (by mouth).

Locally used in the form of a cream, solution or lotion for external use. Apply a thin layer to the affected areas 1-2 times a day. The course of treatment is 4-6 or more (up to 14) weeks. Usually use the drug in 0.05% concentration. With insufficient effect and good tolerability, they are used in a 0.1% concentration. Treated skin should be protected from sunlight. The drug should not fall into the eyes and mucous membranes.

Inside appoint 45mg / m 2 per day (in 2 doses) for 30-90 days (the maximum permissible daily dose for adults and children, respectively, 135 and 60 mg / m 2 ).

Possible side effects: pain in the bones and muscles, weakness, increased intracranial pressure, impaired hearing and vision, dyspepsia, impaired liver and kidney function, alopecia; when applied topically, redness and irritation of the skin.

Contraindicated in pregnancy (probably teratogenic and embryotoxic action).

Method of production: capsules of 0.01 g (N. 100); 0.05% and 0.1% cream in tubes of 20 and 30 g; 0.1% solution for external use in vials of 15 ml; 0.05% lotion in vials of 50 ml; 0.025%; 0.05% and 0.1% gel.