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Description of the medicine: Tretinoin (Tretinoin)
Tretinoin (Tretinoin).
The trans-form of retinoic acid (has the same structure as cis-form - see Isotretinoin).
Synonyms: Airol, Vesanoid, Locacid, Retin-A, Abarel, Acnavit, Acnelyse, Acretin, Airol, Aknoten, Aviderm, Dermairol, Effederm, Locacid, Retin-A, Tretin, Vesanoid and others.
Yellow or light orange crystalline powder. Virtually nerastvorim in water, glycerin and mineral oils; It is difficult to solubilize in ethanol, polyethylene glycol, dimethylsulfoxide.
With topical application for action, it is close to isotretinoin (roaccutane).
When administered internally stimulates the processes of differentiation and inhibits the proliferation of promyelocytes.
With a dermal application, up to 30% of the drug is absorbed. When administered orally, it is absorbed rapidly, C max is 1-2 h, T S is 30 min-2 h; Undergoes biotransformation in the liver, is excreted in urine and feces.
Assign with vulgar and draining eels (locally) and with acute promyelocytic leukemia, resistant to standard chemotherapy (inside).
Locally used as a cream, solution or lotion for external use. Apply a thin layer on the affected areas 1-2 times a day. The course of treatment 4-6 or more (up to 14) weeks. Typically, the drug is used at 0.05% concentration. In case of insufficient effect and good tolerance, 0.1% concentration is used. Treated skin areas should be protected from sunlight. The drug should not fall into the eyes and mucous membranes.
Inside appoint 45 mg / m 2 per day (in 2 admission) for 30-90 days (the maximum permissible daily intake for adults and children is 135 and 60 mg / m 2, respectively).
Possible side effects: pain in the bones and muscles, weakness, increased intracranial pressure, hearing and vision impairment, dyspepsia, impaired liver and kidney function, alopecia; With topical application - redness and irritation of the skin.
Contraindicated in pregnancy (probably teratogenic and embryotoxic effect).
Forms of release: capsules of 0.01 g (N. 100); 0.05% and 0.1% cream in tubes of 20 and 30 g; 0,1% solution for external use in 15 ml vials; 0.05% lotion in 50 ml bottles; 0.025%; 0.05% and 0.1% gel.
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