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Description medications: Filgrastim (Filgrastim)

Filgrastim (Filgrastim).

Synonyms: Neupogen, Neupogen, Neupogen.

Polypeptide (non-glycosylated) comprising 175 amino acid residues. The molecular weight of 8800 Daltons. (C 845 H 1330 N 223 O 243 S 9).

Get a genetically engineered by Escherichia coli. It contains a gene of human granulocyte colony stimulating factor.

It stimulates granulocytopoiesis. Interacting with surface receptors on hematopoietic cells, accelerates biosynthesis and release of neutrophils in the bone marrow.

Applied intravenously and subcutaneously.

Dose set individually depending on the indication, the severity of the process and the patient's susceptibility to the drug.

Treatment starts no earlier than 24 hours after the end of chemotherapy. When administered cytotoxic neutropenia 500 000 units / kg per day, with a bone marrow transplant - by 1 million units / kg per day, with severe chronic neutropenia and congenital starting dose is 1 200 000 IU / kg per day. Treatment is continued until the normalization of blood neutrophils (typically about 2 weeks).

Side effects are rare. However, it may be pain in the bones and muscles, redness and pain at the injection site, and allergic reactions.

Product form: solution for injection into the syringe-tubes of 0.5; 1 and 1.6 ml (30 million and 48 million IU), and vials PA1 ml (30 million units) and 1.6 ml (48 million IU).

Infusion bottle contents diluted in 5% glucose solution.