Description of the medicine: Paracetamol (Paracetamolum)
PARACETAMOL (Paracetamolum). para-acetaminophenol.
Synonyms: Opradol, Panadol, Ushamol, Abesanil, Acelifen, Acemol, Acetalgin, Acetaminophen, Acetaminophenol, Actasol, Algotropyl, Alvedon, Aminophen, Amphenol, Apagan, Apamide, Apanol, Biocetamolethelapetifelaplifapelifaplif, Chepanet Dexamol, Dimindol, Dolamin, Dolanex, Dolipram, Efferalgan, Erocetamol, Febridol, Febrinil, Febrinol, Fendon, Metamol, Minoset, Myalgin, Napamol, Naprinol, Nasprin, Nysacetol, Opradol, Pacemol, Panadol, Pyadram, Panadol, Pyadon Pyrinazin, Rolocin, Tempramol, Tralgon, Tylemin, Tylenol, Ushamol, Valadol, Valgesic, Valorin, Volpan, Winadol, etc.
Crystal powder, white or white with a cream or pink tint. Easily soluble in alcohol, insoluble in water.
Paracetamol is chemically similar to phenacetin. It is the main metabolite that quickly forms in the body when taking phenacetin; apparently, causes the analgesic effect of the latter. In terms of analgesic activity, paracetamol does not significantly differ from phenacetin; like phenacetin, it has a weak anti-inflammatory activity. The main advantages of paracetamol are less toxicity, less ability to cause the formation of methemoglobin. However, this drug may also cause side effects; with prolonged use, especially in large doses, paracetamol may have nephrotoxic and hepatotoxic effects.
Paracetamol is absorbed in the upper intestine, metabolized in the liver, excreted mainly by the kidneys.
Indications for use are the same as for amidopyrine and phenacetin.
Doses for adults 0.2 - 0.4 g per reception 2 - 3 times a day.
Higher doses for adults inside: single 0.5 g daily 1, 5 g.
Children aged 6 to 12 months are prescribed at 0.025 - 0.05 g, 2 - 5 years - at 0.1 - 0.15 g, 6 - 12 years - at 0.15 - 0.25 g per reception 2 - 3 times a day.
When using paracetamol, liver function, the condition of the hematopoietic system should be monitored; allergic reactions are possible.
Method of release: powder and tablets of 0.2 g.
Storage: List B. In a well-sealed container that protects from the action of light: tablets - in a place protected from light.
Recently, due to the limited use of amidopyrine and phenacetin, paracetamol and combined dosage forms containing paracetamol have become relatively widely used (in combination with acetylsalicylic acid, analgin, caffeine, codeine, etc.).
Abroad, paracetamol (panadol, panadone) is available in various dosage forms: in the form of tablets, capsules, medicine, syrup, "effervescent" powders. There are a number of combined dosage forms containing paracetamol in combination with caffeine, codeine and other drugs;
The Republic of Korea produces Coolpain-S (Culpein-S; Culpan-C) - tablets containing 0.5 g of paracetamol and 0.25 g of methionine.
Rp .: Tab. Paracetamoli 0.2 N. 10
DS 1 tablet 3 times a day
Rp .: Paracetamoli
Ac. acetylsalicylici aa 0.25
Coffeini natrio-benzoatis o, l