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Medication Description: Paracetamol (Paracetamolum)

PARACETAMOL (Paracetamolum). para-Acetaminophenol.

Synonyms: Opradol, Panadol, Ushaamol, Abesanil, Acelifen, Acemol, Acetalgin, Acetaminophen, Acetaminophenol, Actasol, Algotropyl, Alvedon, Aminophen, Amphenol, Apanide, Apelide, Apelide, Apelide Dexamol, Dimindol, Dolamin, Dolanex, Dolipram, Efferalgan, Erocetamol, Febridol, Febrinil, Febrinol, Fendon, Metamol, Minoset, Myalgin, Napamol, Naprinol, Nasprin, Nysacetol, Opradol, Pacemol, Panadol, aphrodol, Napadol, Naprinol, Nasprin, Nysacetol; Pyrinazin, Rolocin, Tempramol, Tralgon, Tylemin, Tylenol, Ushamol, Valadol, Valgesic, Valorin, Volpan, Winadol, etc.

White or white with cream or pink tinge crystalline powder. Easily soluble in alcohol, insoluble in water.

Paracetamol is chemically close to phenacetin. It is the main metabolite, rapidly forming in the body when taking phenacetin; apparently, causes the analgesic effect of the latter. Paracetamol is not significantly different from phenacetin in the analgesic activity; like phenacetin, it has a weak anti-inflammatory activity. The main advantages of paracetamol are less toxicity, less ability to cause the formation of methemoglobin. However, this drug may also cause side effects; with prolonged use, especially in large doses, paracetamol may have nephrotoxic and hepatotoxic effects.

Paracetamol is absorbed in the upper intestine, metabolized in the liver, excreted mainly by the kidneys.

Indications for use are the same as for amidopirin and phenacetin.

Doses for adults 0.2 - 0.4 g per reception 2 - 3 times a day.

Higher doses for adults inside: single 0.5 g daily 1, 5 g

Children aged from 6 to 12 months prescribed by 0.025 - 0.05 g, 2 - 5 years - 0.1 - 0.15 g, 6 - 12 years - 0.15 - 0.25 g per reception 2 - 3 times a day.

When using paracetamol should monitor liver function, the state of the hematopoietic system; allergic reactions are possible.

Method of issuance: powder and tablets of 0.2 g.

Storage: List B. In a well-closed container that protects against the action of light: tablets - in a dark place.

Recently, in connection with the restriction of the use of amidopirin and phenacetin, paracetamol and combined dosage forms containing paracetamol (in combination with acetylsalicylic acid, analgin, caffeine, codeine, etc.) have become relatively widely used.

Abroad, paracetamol (Panadol, Panadone) is available in different dosage forms: in the form of tablets, capsules, medicines, syrup, << effervescent >> powders. There are a number of combination dosage forms containing paracetamol in combination with caffeine, codeine and other drugs;

In the Republic of Korea, the drug Coolpain-S (kulpain-S; kulpan-C) is available - tablets containing 0.5 g of paracetamol and 0.25 g of methionine.

Rp .: Tab. Paracetamoli 0,2 N. 10

DS 1 tablet 3 times a day

Rp .: Paracetamoli

Ac. acetylsalicylici aa 0,25

Coffeini natrio-benzoatis O, l

Mf pulv.

DtdN 10