Medication Description: Azithromycin (Azithromycinum)
Synonyms: Azivok, Azitroks, Azitrotsin, Zimaks, Zitrolid, Sumazid, Sumamed, Azitromycin, Azivok, Sumamed, Zimax.
An antibiotic from the macrolide group, isolated into a new subgroup of azalides.
It is a semi-synthetic derivative of erythromycin.
It has a wide range of antimicrobial action. It is highly effective against both gram-positive (staphylococci, streptococci, pneumococci), including the peas producing β-lactamase, and gram-negative (enterococci, intestinal and hemophilic bacilli, gonococci, legionella, shigella, salmonella) of the microorganisms, and an aspirant, aspirastroma, aspirantine, gonococci, legionella, shigella, salmonella) , chlamydia, as well as mycoplasma and spirochetes.
Compared with erythromycin, it is more active against gram-negative microorganisms, it is more stable in the acidic environment of the stomach, it is more slowly excreted from the body and acts longer; better tolerated; inhibits cytochrome P-450 of the liver to a lesser extent.
In high concentrations has a bactericidal effect.
Rapidly absorbed in the gastrointestinal tract (stable in an acidic environment), bioavailability is about 37%, C max - 2.5-3 hours, T Ѕ - 14-68 hours; penetrates organs and tissues well; bactericidal concentration in the outbreak of infectious inflammation is maintained for 5-7 days after the last dose; undergoes biotransformation in the liver, excreted mainly with bile.
Applied azithromycin in diseases caused by microorganisms sensitive to it, including angina, pneumonia, bronchitis, pharyngitis, laryngitis, sinusitis, otitis, scarlet fever, erysipelas, acne, chlamydial urethritis and cervicitis, gonorrheal and negonoreyny borreliosis (Lyme disease), atypical bacterial diseases with AIDS and other infectious diseases.
Also used in the treatment of gastric ulcer and duodenal ulcer associated with Helicobacter pylori.
Assign inside (1 hour before or 2 hours after a meal), usually for adults 0.5 g 1 time a day for 3 days or on the 1st day 0.5 g 1 time per day, from the 2nd to 5 day - 0.25 g 1 time per day; with urogenital diseases - 1 g once. Children over 12 months of age are given 10 mg / kg on day 1, then 5 mg / kg 1 time per day for 4 days.
Allergic reactions, nausea, vomiting, cholestasis, jaundice are possible.
The drug is contraindicated in marked disorders of the liver and kidneys.
Caution is prescribed for cardiac arrhythmias.
Method of production: tablets of 0.125 g (N. 6) and 0.5 g (N. 3); capsules of 0.25 g (N. 6); 2% and 4% (forte) syrup; granulated powder for 2% and 4% suspension for oral administration for children in vials of 0.1 and 0.2 g; films (sterile wipes) (0.3-0.5 g / g).
Some other macrolide antibiotics are also registered in Russia: Josamycin. Synonym: Wilprafen, Wilprafen. Dirithromycin (Dirithromycin). Synonyms: Dinabac, Dinabac.