Description of the medicine: Azithromycin (Azithromycinum)

AZITHROMYCIN (Azithromycinum).

Synonyms: Azivok, Azitrox, Azitrocin, Zimaks, Zitrolide, Sumazid, Sumamed, Azitromycin, Azivok, Sumamed, Zimax.

Antibiotic from the group of macrolides, isolated in a new subgroup of azalides.

It is a semisynthetic derivative of erythromycin.

Has a wide spectrum of antimicrobial action. Highly effective against both gram-positive (staphylococci, streptococci, pneumococci), including β-lactamase-producing, and Gram-negative (enterococci, intestinal and hemophilic rods, gonococci, legionella, shigella, salmonella) microorganisms, anaerobes (bacteroides, clostridia, peptococci) , Chlamydia, as well as mycoplasmas and spirochaetes.

Compared with erythromycin, it is more active against gram-negative microorganisms, it is more stable in the acidic environment of the stomach, it is more slowly released from the body and lasts longer; Better tolerated; To a lesser extent inhibits cytochrome P-450 liver.

In a large concentration has a bactericidal effect.

Quickly absorbed in the digestive tract (resistant to acidic environment), bioavailability is about 37%, C _max - 2,5-3 h, T _S - 14-68 h; Well penetrates into organs and tissues; Bactericidal concentration in the focus of infectious inflammation is maintained for 5-7 days after the last dose; Undergoes biotransformation in the liver, is excreted primarily with bile.

Azithromycin is used for diseases caused by sensitive microorganisms, including tonsillitis, pneumonia, bronchitis, pharyngitis, laryngitis, sinusitis, otitis, scarlet fever, erysipelas, acne, chlamydial urethritis and cervicitis, gonorrhea and non-gonorrhea borreliosis (Lyme disease), atypical bacteriosis with AIDS and other infectious diseases.

They are also used in the complex therapy of gastric ulcer and duodenal ulcer associated with Helicobacter pylori.

Assign inside (usually 1 hour before or 2 hours after eating) usually adults 0.5 g once a day for 3 days or on the 1st day 0.5 g once a day, from 2 to 5 -th day - 0.25 g once a day; With urogenital diseases - 1 g once. Children older than 12 months are administered on the first day of 10 mg / kg, then for 4 days to 5 mg / kg 1 time per day.

Possible allergic reactions, nausea, vomiting, cholestasis, jaundice.

The drug is contraindicated in severe violations of the liver and kidneys.

Be wary of cardiac arrhythmias.

Forms of release: tablets of 0.125 g (N. 6) and 0.5 g (N. 3); Capsules of 0.25 g (N. 6); 2% and 4% (forte) syrup; Granulated powder for 2% and 4% suspension for oral administration for children in vials of 0.1 and 0.2 g; Film (sterile wipes) (0.3-0.5 g / g).

In Russia, some other macrolide antibiotics have also been registered: Josamycin. Synonym: Wilprafen, Wilprafen. Dirithromycin (Dirithromycin). Synonyms: Dinabac, Dinabac.