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Description of the medicine: Azithromycin (Azithromycinum)

Azithromycin (Azithromycinum).

Synonyms: Azivoc, Azitrox, Azitrocin, Zimax, Zitrolide, Sumazid, Sumamed, Azitromycin, Azivok, Sumamed, Zimax.

Antibiotic from the macrolide group, isolated in a new subgroup of azalides.

It is a semi-synthetic derivative of erythromycin.

It has a wide range of antimicrobial effects. Highly effective against both gram-positive (staphylococci, streptococci, pneumococci), including those producing β-lactamase, and gram-negative (enterococci, intestinal and hemophilic bacilli, gonococci, legionella, shigella, salmonella) microorganisms, anaerobes, anaerobes, anaerobes, , chlamydia, as well as mycoplasmas and spirochetes.

Compared with erythromycin, it is more active against gram-negative microorganisms, it is more stable in the acidic environment of the stomach, it is more slowly excreted from the body and lasts longer; better tolerated; to a lesser extent inhibits the cytochrome P-450 of the liver.

In high concentration it has a bactericidal effect.

Quickly absorbed in the digestive tract (stable in an acidic environment), bioavailability is about 37%, C max - 2.5-3 hours, T Ѕ - 14-68 hours; penetrates well into organs and tissues; bactericidal concentration in the focus of infectious inflammation is maintained for 5-7 days after the last dose; subjected to biotransformation in the liver, excreted mainly with bile.

Azithromycin is used for diseases caused by microorganisms sensitive to it, including sore throats, pneumonia, bronchitis, pharyngitis, laryngitis, sinusitis, otitis media, scarlet fever, erysipelas, acne, chlamydial urethritis and cervicitis, gonorrhea and non-gonorrhea borreliosis, and Lyme disease AIDS and other infectious diseases.

Also used in the treatment of gastric ulcer and duodenal ulcer associated with Helicobacter pylori.

Assign inside (1 hour before or 2 hours after eating), usually adults, 0.5 g 1 time per day for 3 days or on the 1st day 0.5 g 1 time per day, from 2 to 5 day - 0.25 g once a day; with urogenital diseases - 1 g once. Children over 12 months of age are given 10 mg / kg on the 1st day, then 5 mg / kg once a day for 4 days.

Allergic reactions, nausea, vomiting, cholestasis, jaundice are possible.

The drug is contraindicated in severe violations of the liver and kidneys.

With caution prescribed for cardiac arrhythmias.

Method of release: tablets of 0.125 g (N. 6) and 0.5 g (N. 3); capsules of 0.25 g (N. 6); 2% and 4% (forte) syrup; granular powder for 2% and 4% oral suspension for children in vials of 0.1 and 0.2 g; films (sterile wipes) (0.3-0.5 g / g).

In Russia, some other antibiotics of the macrolide group are also registered: Josamycin (Josamycin). Synonym: Wilprafen, Wilprafen. Dirithromycin (Dirithromycin). Synonyms: Dinabac, Dinabac.