Medication Description: Acetylsalicylic Acid (Acidum acetylsalicylicum)
ACETYLSALICYL ACID (Acidum acetylsalicylicum).
Synonyms: Anopyrin, Apo-Asa, Aspivatrin, Aspilaight, Aspinate, Aspirin, Aspirin-Direct, Aspirin-Cardio, Aspirin UPSA, Aspitrin, ACC-Ratiopharm, Acterin, Acetylsalicylbene, Acylpyrin, ACC, Accephrine, ACC-Ratiopharm, Acterin, Acetylsalicylbene, Acylpyrin, ACC, Accepirin, ACC-Ratiopharm, Accentrin, Acetylsalicylbene, Acylpyrin, ACC, Accentrin, ACC-Ratiopharm Bufferan, Bufferin, Kolpharit, Mikristin, Our choice is an analgesic, Novandol, Novasan, Novasen, New Aspar, NU-Silz 75 cardio-aspirin, Plydol, Ronal, Salorin, Sprit-Lyme, Trombo ASS, Walsh-Asalgin, Upsarin UPSA , HSBC E Payne, Elkapin, Acenterin, Acesal, Acetosal, Acetylin, Acetylsalicylbene, Acetylsalicylic Acid, Acetysal, Acylpyrin, Anopyrin, Apo-Asa, Aspilite, Aspirin, Aspisol, Aspivatrin, Asposal, Aspro, Astrin, Ataspin, Bartell drugs ASA, Bayaspirin, B ebaspin, Benaspir, Bispirine, Bufferan, Bufferin, Caprin, Cetasal, Citopyrine, Clariprin, Colfarit, Darosal, Durasal, Easprin, Elkapin, Endosalil, Endospirin, Eutosal, Genasprine, Helicon, HL-Paim, isopros, citrus, Citrus, Eros, Erosaline, Helicon, Hichen, Hir-Anthiny New-asper, Novandol, Novasan, Novasen, Novosprin, NU-seals 75 cardio-aspirin, Our choice - analgetic, Panspiril, Plidol, Polopiryna, Prodol, Rhonal, Rodopytin, Ronal, Ruspirm, Salacetin, Saletin, Salorin, Sprit-Lime , Temperal, Trombo ASS, Vicapirine, Walsh-asalgin, Zorprin, etc.
White small needles or light crystalline powder. It is little soluble in water (it is soluble in hot water), it is easy - in alcohol, in solutions of caustic and carbonic alkalis.
Acetylsalicylic acid has anti-inflammatory, antipyretic, as well as analgesic effect, and it is widely used in feverish conditions, head pain, migraine 2 , neuralgia, and as an antirheumatic agent.
The anti-inflammatory effect of acetylsalicylic acid (and other sadicylates) is explained by its influence on the processes occurring in the inflammatory focus: a decrease in capillary permeability, a decrease in the activity of hyaluronidase, a restriction of the energy supply of the inflammatory process by inhibiting the formation of ATP, etc. In the anti-inflammatory mechanism, inhibit the inhibitory effect. prostaglandins.
The antipyretic effect is associated with the effect of thermoregulation on the hypothalamic centers.
The analgesic effect is due to the effect on the centers of pain sensitivity and the ability of salicylates to reduce the algogenic effect of bradykinin.
An important feature of acetylsalicylic acid, which has recently been given great importance, is the ability to exert an antiaggregatory effect (inhibit spontaneous and induced platelet aggregation).
Substances with anti-aggregation effect began to be widely used in medicine for the correction of hemorheological disorders and prevention of thrombotic complications in patients with myocardial infarction, cerebral circulation disorders and other cardiovascular diseases. In this regard, it is appropriate to distinguish these substances in the group of antiaggregatory agents. These properties of acetylsalicylic acid are discussed in the appropriate section (see. Antiplatelet agents).
Acetylsalicylic acid stimulates the excretion of uric acid as a result of a violation of its reabsorption in the tubules of the kidneys.