Description of the medicine: Acetylsalicylic acid (Acidum acetylsalicylicum)
ACETYL SALICYLIC ACID (Acidum acetylsalicylicum).
Synonyms: Anopyrin, Apo-Asa, Aspivatrin, Aspilayt, Aspinat, Aspirin, Aspirin-direct, Aspirin-cardio, Aspirin UPSA, Aspitrin, ACC-Ratiofarm, Acenterin, Acetylsalicylbene, Atzilzirin B., Atsilzirin B, C., B. Bufferan, Bufferin, Colfarit, Mikristin, Our choice - analgesic, Novandol, Novasan, Novasen, New Aspar, NU-Sils 75 cardio-aspirin, Plidol, Ronal, Salorin, Sprite-Lyme, Trombo ACC, Walsh-asalgin, Upsarin UPSA , H-El-Payne, Elkapin, Acenterin, Acesal, Acetosal, Acetylin, Acetylsalicylbene, Acetylsalicylic Acid, Acetysal, Acylpyrin, Anopyrin, Apo-Asa, Aspilite, Aspirin, Aspisol, Aspivatrin, Aspinal, Atposell, Asposal, Asposal, Asposal, Asposal, ASA, Bayaspirin, B ebaspin, Benaspir, Bispirine, Bufferan, Bufferin, Caprin, Cetasal, Citopyrine, Clariprin, Colfarit, Darosal, Durasal, Easprin, Elkapin, Endosalil, Endospirin, Eutosal, Genasprine, Helicon, HL-Paim, Isopirin, Iopirin, Iopirin, Micopril, Micopril New-asper, Novandol, Novasan, Novasen, Novosprin, NU-seals 75 cardio-aspirin, Our choice - analgetic, Panspiril, Plidol, Polopiryna, Prodol, Rhonal, Rodopytin, Ronal, Ruspirm, Salacetin, Saletin, Salorin, Sprit-Lime , Temperal, Trombo ASS, Vicapirine, Walsh-asalgin, Zorprin, etc.
White fine needle crystals or a light crystalline powder. It is slightly soluble in water (soluble in hot water), easily soluble in alcohol, in solutions of caustic and carbonic alkalis.
Acetylsalicylic acid has an anti-inflammatory, antipyretic, and also analgesic effect, and it is widely used for febrile conditions, headache, migraine 2 , neuralgia, and as an antirheumatic agent.
The anti-inflammatory effect of acetylsalicylic acid (and other sadicylates) is explained by its effect on the processes occurring in the focus of inflammation: a decrease in the permeability of capillaries, a decrease in the activity of hyaluronidase, a limitation in the energy supply of the inflammatory process by inhibiting the formation of ATP, etc. Inhibition of biosynthesis is important in the mechanism of anti-inflammatory action prostaglandins.
Antipyretic effect is associated with the influence on the hypothalamic centers of thermoregulation.
The analgesic effect is due to the effect on the centers of pain sensitivity and the ability of salicylates to reduce the algogenic effect of bradykinin.
An important feature of acetylsalicylic acid, which has recently been given great importance, is the ability to exert an anti-aggregation effect (inhibit spontaneous and induced platelet aggregation).
Substances with anti-aggregation action began to be widely used in medicine for the correction of hemorheological disorders and the prevention of thrombotic complications in patients with myocardial infarction, cerebrovascular diseases and other cardiovascular diseases. In this regard, it is appropriate to isolate these substances in the group of anti-aggregation agents. These properties of acetylsalicylic acid are considered in the appropriate section (see Antiplatelet agents).
Acetylsalicylic acid stimulates the excretion of uric acid as a result of a violation of its reabsorption in the tubules of the kidneys.