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Description of the medicine: Bicalutamide (Bicalutamide)


(±) -4ґ-Cyano-α, α, α-trifluoro-3 - [(p-fluorophenyl) sulfonyl] -2-methyl-meta-lactotoluide.

Synonym: Casodex, Casodex.

White crystalline powder. Virtually nerastvorim in water, poorly soluble in chloroform and ethanol, it is difficult - in methanol, soluble in acetone.

The blocker of androgen receptors.

When ingested quickly and completely absorbed, T составляет is about 7 days; Undergoes biotransformation in the liver, is excreted in urine and feces.

Applied with prostate cancer.

Assign inside at 0,05-0,15 g (50-150 mg) once a day every day. Usually used in combination with goserelin (see).

Possible side effects: dyspepsia, gynecomastia, xerostomia, decreased libido, peripheral edema, angina pectoris and heart failure, gastric bleeding, depression, hyperglycemia, myalgia, arthralgia, urinary retention, allergic reactions, etc.

The drug should not be given to women and children.

Form release: tablets of 0.05 and 0.15 g (N. 28).

Storage: List B.

Other inhibitors of 5-α-reductase (epristeride-Epristeride, etc.), acting like finasteride and similar in structure, have been developed.