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Description medications: didanosine (Didanosine)

DdI (Didanosine).

2 ', 3'-dideoxyinosine.

Synonym: Videx, Videx.

The white crystalline powder. Soluble in water. Unstable in an acidic environment.

The structure and action similar to other nucleoside antiviral. In the cells of the body turns into dideoxyadenosine 5'-triphosphate inhibits the activity of reverse transcriptase of HIV-1.

When ingestion bioavailability of approximately 30%, C max - 0,5-1 h, T ½ - 0,8-2,7 hours; excreted by the kidneys.

Applied mostly with HIV.

Assign inside a pill or a powder for 30 minutes before a meal. Tablets chewed, crushed or carefully by hand, or dispersed in ¼ cup of water. The powder is diluted in 1 cup water.

Adults weighing over 60 kg are administered in tablets or 0.2 g powder of 0.25 g of 2 times a day (at intervals of 12 hours), with a body weight less than 60 kg - 0.12 g, or and 0.167 g, respectively, 2 times a day; children - a rate of 0.12 g / m 2, 2 times a day.

Possible side effects: diarrheal phenomenon, depigmentation of the retina, peripheral neuropathy, hyperuricemia, hyperglycemia, impaired liver function, and pancreatic, blood oppression, allergic reactions, etc.

Contraindications pancreatitis, gout, kidney failure, liver cirrhosis, hypertension, heart failure, hypertriglyceridemia, pregnancy and breastfeeding.

production: tablets for chewing or for the solution (suspension) for intake to 0,025; 0.05; 0.1 and 0.15 g (N. 60); powder for oral solution sachets of 0.1; 0.167; 0.25 and 0.375 g and in bottles of 2 and 4 years

Storage: List B.