Before taking the course, consult a doctor!
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Description of the medicine: Irinotecan (Irinotecan)
IRINOTECAN.
(+) - 7-Ethyl ester of 10-hydroxy-camptodecin-10- (1,4ґ-bipiperidine) -1ґ-carboxylic acid (hydrochloride).
Synonyms: Campto, Campto, Camptosar.
Pale yellow or yellow crystalline powder. Soluble in water and organic solvents.
Semisynthetic derivative of camptothecin alkaloid isolated from the stems of the bush Campotheca acuminata.
Inhibiting DNA - topoisomerase I, blocks the replication of DNA in the S-phase of the cell cycle.
Applied with metastasizing colon cancer (colorectal cancer) in the absence of the effect of 5-fluorouracil, as well as lung cancer, ovaries and cervix.
Enter intravenously (within 30 minutes) at a rate of 0.35 g / m 2 1 time per 3 weeks.
Possible side effects: acute cholinergic syndrome (sweating, tearing and salivation, diarrhea - the first day after the infusion), dyspepsia, stomatitis, involuntary muscle contraction, paresthesia, alopecia, fever, neutropenia, leukopenia, thrombocytopenia, anemia, skin allergic reactions.
Contraindications: chronic intestinal diseases, neutropenia, pregnancy, breast-feeding.
Product: 2% solution for infusions in bottles of 2 and 5 ml.
Storage: List B.
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