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Description of the medicine: Itraconazole (Itraconazole)

ITRAKONAZOLE (Itraconazole).

4- [4- [4- [4 - [[2- (2,4-Dichlorophenyl) -2- (1H-1,2,4-triazol-1-yl-methyl) -1,3-dioxolan-4 -yl] methoxy] phenyl] piperazinyl] phenyl] -2,4-dihydro-2- (1-methoxypropyl) -3H-1,2,4-triazol-3-one.

Synonyms: Kanazol, Orungal, Sporanox, Kanazol, Orungal, Sporanox.

White powder with a slightly yellowish tint. Insoluble in water, slightly soluble in ethanol and well in dichloromethane.

A broad-spectrum antifungal drug. It is active against dermatophytes, yeast, yeast-like and mold fungi, pathogens of endemic mycoses.

When administered orally, it is absorbed almost completely, C max is 3-4 hours, T Ѕ - 24-36 hours; penetrates tissues and organs; undergoes biotransformation in the liver, is excreted slowly (within 1 week) with urine and feces.

It is used for candidiasis of various localization, dermatomycosis (including severe lesions of the hands and feet), onychomycosis, multi-colored lichen, sporotrichosis, blastomycosis, histoplasmosis, aspergillosis, cryptococcosis, coccidiodosis, paracoccidioidomycosis.

High efficacy in ophthalmic mycoses was noted.

Assign inside (with food).

With onychomycosis, 0.2 g is used 2 times a day for 7 days (2-3 courses with a 3-week break) or in the same dose 1 time per day for 3 months.

For the treatment of dermatomycosis, 0.1-0.2 g is prescribed 1 time per day for 7-15 days or more.

With genital candidiasis, 0.2 g 2 times a day is used on the first day, then for 3 days at the same dose 1 time per day.

For the treatment of candidiasis of the oropharyngeal region, 0.1 g is prescribed 1 time per day for 15 days.

With systemic aspergillosis, candidiasis, histoplasmosis and blastomycosis, they take 0.1-0.2 g 1-2 times a day from 1-2 months to 1 year.

Possible side effects: dyspeptic symptoms, impaired liver function, cholestatic jaundice, edema, hyperkalemia, hypoglycemia, arterial hypotension, peripheral neuropathies, allergic reactions, menstrual irregularities.

Method of release: capsules of 0.1 g (N. 15); 1% oral solution in 150 ml vials.

Storage: List B.