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Medication Description: Itraconazole (Itraconazole)

Itraconazole (Itraconazole).

4- [4- [4- [4 - [[2- (2,4-Dichlorophenyl) -2- (1H-1,2,4-triazol-1-yl-methyl) -1,3-dioxolane-4 -yl] -methoxy] phenyl] piperazinyl] phenyl] -2,4-dihydro-2- (1-methoxypropyl) -3H-1,2,4-triazol-3-one.

Synonyms: Kanazol, Orungal, Sporanox, Kanazol, Orungal, Sporanox.

White with a slightly yellowish tinge powder. It is insoluble in water, slightly soluble in ethanol and good in dichloromethane.

Antifungal broad-spectrum drug. It is active against dermatophytes, yeast, yeast-like and mold fungi, pathogens of endemic mycoses.

With the introduction of the inside absorbed almost completely, C max is 3-4 hours, T Ѕ - 24-36 hours; penetrates tissues and organs; Biotransformation in the liver is excreted slowly (within 1 week) with urine and feces.

Applied with candidiasis of various localization, ringworm (including severe lesions of the hands and feet), onychomycosis, multi-colored lichen, sporotrichosis, blastomycosis, histoplasmosis, aspergillosis, cryptococcosis, coccidiosis, paracoccidioidomycosis.

High efficiency at ophthalmomycosis is noted.

Assign inside (during meals).

For onychomycosis, apply 0.2 g 2 times a day for 7 days (2-3 courses with a 3-week break) or at the same dose once a day for 3 months.

For the treatment of ringworm prescribed 0.1-0.2 g 1 time per day for 7-15 days or more.

For genital candidiasis, 0.2 g is applied on the first day, 2 times a day, then for 3 days in the same dose 1 time a day.

For the treatment of candidiasis of the oropharyngeal region, 0.1 g is prescribed once a day for 15 days.

For systemic aspergillosis, candidiasis, histoplasmosis and blastomycosis, take 0.1-0.2 g 1-2 times a day from 1-2 months to 1 year.

Possible side effects: dyspeptic symptoms, impaired liver function, cholestatic jaundice, edema, hyperkalemia, hypoglycemia, arterial hypotension, peripheral neuropathy, allergic reactions, menstrual disorders.

Method of production: capsules of 0.1 g (N. 15); 1% solution for oral administration in bottles of 150 ml.

Storage: List B.