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Description of the medicine: Capecitabine (Capecitabine)

Capecitabine (Capecitabine).

Pentyl 1- (5-deoxy-β-D-ribofuranosyl) -5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamate.

Synonym: Xeloda, Xeloda.

Like fluoroufur, it is a prodrug of fluorouracil (it is converted into it in tumor cells).

Antimetabolite of pyrimidine (inhibits thymidylate synthetase).

Quickly and completely absorbed in the gastrointestinal tract, C max is 1.5 h, T S is 3-4 h, biotransformation is performed in the liver and tumor cells, is excreted mainly by the kidneys.

Applied with cancer of the colon, breast, ovaries.

Assign inside (after 30 minutes after eating) at 2.5 g / m 2 per day (in 2 divided doses) for 2 weeks, a second course after 1 week.

Possible side effects: neutropenia, thrombocytopenia, anemia, dry mouth, anorexia, dyspepsia, paresthesia, swelling, lacrimation, hyperpigmentation.

Contraindications: pregnancy, breast-feeding.

Form release: tablets of 0.15 g (N. 60) and 0.5 g (N. 120).