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Description medications: Carmustine (Carmustine)

Carmustine (Carmustine).

1,3-bis (2-chloromethyl) -1-nitrosourea.

Synonym: BiCNU, BiCNU.

Freeze-dried weight of flakes or pale yellow. It is soluble in alcohol, poorly - in water. It has a low melting point (30 ° C).

Like nimustine lomustine and contains in the molecule chloroethyl radical.

By activity and toxicity similar to lomustine.

The drug and its metabolites are rapidly penetrating the blood-brain barrier; found in high concentrations in the cerebrospinal fluid.

Apply with brain tumors and gastrointestinal tract, multiple myeloma, Hodgkin disease, malignant melanoma, Ewing's sarcoma.

Enter intravenously at 200 mg / m 2 once (the first time patients receive medical treatment) or 75-100 mg / m 2 for 2 consecutive days every 6 weeks. The drug was dissolved in 3 ml of solvent, and then supplied into a 27 ml sterile water for injection.

When combined with other drugs to reduce the dose of 25-50%.

Product: dried powder for injection solutions in vials of 0.1 g complete with a solvent (3 mL).