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Description of the medicine: Lomefloxacin (Lomefloxacin)

LOMEFLOXACIN (Lomefloxacin).

1-Ethyl-6,8-difluoro-1,4-dihydro-7- (3-methyl-1-piperazinyl) -4-oxo-3-quinolinecarboxylic acid.

Synonyms: Lomflox, Maxavin, Okatsin, Lomexid, Lomflox, Maxaquin, Ocacin.

White to pale yellow powder. Slightly soluble in water and practically insoluble in alcohol. Sensitive to light in aqueous solution.

Available in the form of hydrochloride.

One of the most active modern antibacterial drugs of the fluoroquinolone group. The presence of two fluorine atoms and a methyl group in the piperazine nucleus in the lomefloxacin molecule (see the formulas of pefloxacin, norfloxacin, ciprofloxacin) contributes to its rapid and prolonged action in the body.

Active against most gram-negative and some gram-positive (staphylococci) aerobic bacteria, chlamydia and mycobacterium tuberculosis.

When ingested quickly and completely absorbed, C max is 0.8-1.5 hours, T ч - 8-9 hours; penetrates well into organs and tissues; undergoes minor biotransformation, excreted by the kidneys.

Used for infections of the urinary tract (cystitis, pyelonephritis, urethritis, prostatitis) and lower respiratory tract, gastrointestinal tract (dysentery, typhoid fever, salmonellosis) and biliary tract, ENT organs, skin, soft tissues, bones, pelvic organs, with gonorrhea, chlamydia and other infections caused by microorganisms sensitive to fluoroquinolones.

It is also effective for bacterial infections of the anterior chamber of the eye (blepharitis, conjunctivitis and blepharo-conjunctivitis).

Recently, lomefloxacin has been classified as anti-TB drugs (see). It is prescribed in combination with conventional anti-TB drugs, since tuberculosis infection is often accompanied by nonspecific infectious lesions.

Apply inside and topically.

Inside, adults are usually prescribed 0.4 g (up to 0.8 g) once a day. In case of impaired renal function, a dose of 0.4 g is used on the first day, then 0.2 g per day. The course of treatment is from 3-5 days for urinary tract infections, uncomplicated dysentery, enterocolitis and chronic gonorrhea up to 3-8 weeks for chronic osteomyelitis.

In ophthalmic practice, 5 drops of a 0.3% solution are instilled under the conjunctiva for 20 minutes and 1 drop per hour for 6-10 hours, then 1 drop 2-3 times a day for 7-9 days.

When taking lomefloxacin, pain in the epigastric region, diarrhea, headache, dizziness, dysuria, impaired urination, photosensitivity are possible.

The drug is contraindicated with a predisposition to convulsions, during pregnancy and lactation, under the age of 18 years.

Method of release: tablets of 0.4 g (N. 5, 7, 10); 0.3% solution (eye drops) in 5 ml vials.

Storage: List B.