This page has been robot translated, sorry for typos if any. Original content here.

Attention! The information is for reference only!
Before taking, be sure to consult a doctor!
SITE ONLY DIRECTORY. NOT A PHARMACY! We do not sell medicines! None!

Description of the medicine: Lomustin (Lomustin)

LOMUSTIN (Lomustin).

1- (2-Chloroethyl) -3-cyclohexyl-1-nitrosourea.

Synonym: SiNU, CeeNu.

A creamy white crystalline powder. Slightly soluble in water and alcohol, soluble in acetone, dimethyl sulfoxide and dimethylformamide. Thermally unstable, melts with decomposition.

Contains in the molecule, along with a fragment of nitrosourea, a chloroethyl radical.

Alkylates phosphate, amine, hydroxyl, sulfhydryl and carboxyl groups, causes crosslinking and DNA breaks.

Quickly absorbed in the digestive tract, C max is 1-4 hours; different ability to easily penetrate the blood-brain barrier.

Used for tumors of the brain, lungs, gastrointestinal tract, kidneys, lymphogranulomatosis, malignant lymphoma, melanoma, myeloma and lymphosarcoma.

Assign orally in a dose of 100-130 mg per 1 m 2 of the body surface once every 6 weeks or 75 mg / m 2 every 3 weeks.

Leukopenia, thrombocytopenia, nausea, vomiting, anorexia, stomatitis, alopecia, liver dysfunction, menstrual irregularities can be observed.

Contraindications: hematopoiesis (myelosuppression), severe hepatic and renal impairment, pregnancy, breast-feeding.

Method of release: tablets of 0.04 g (40 mg) (N. 50); capsules of 0.01; 0.04 and 0.1 g (N. 20).