Before taking the course, consult a doctor!
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Description of the medicine: Lomustin (Lomustin)
LOMUSTIN (Lomustin).
1- (2-Chloroethyl) -3-cyclohexyl-1-nitrosourea.
Synonym: Sinyu, CeeNu.
A creamy white crystalline powder. Poorly soluble in water and alcohol, soluble in acetone, dimethyl sulfoxide and dimethylformamide. It is thermally unstable, melts with decomposition.
Contains in the molecule, along with a fragment of nitrosourea, the chloroethyl radical.
Alkylates phosphate, amine, hydroxyl, sulfhydryl and carboxyl groups, causes crosslinks and DNA breaks.
Quickly absorbed in the gastrointestinal tract, C max is 1-4 hours; Differs ability to easily penetrate the blood-brain barrier.
Applied with tumors of the brain, lungs, digestive tract, kidneys, lymphogranulomatosis, malignant lymphoma, melanoma, myeloma and lymphosarcoma.
Assign inside the dose of 100-130 mg per 1 m 2 of the body surface 1 time in 6 weeks or 75 mg / m 2 every 3 weeks.
There may be leukopenia, thrombocytopenia, nausea, vomiting, anorexia, stomatitis, alopecia, violations of the liver, menstrual irregularities.
Contraindications: hemopoiesis disorders (myelosuppression), expressed violations of liver and kidney functions, pregnancy, breast-feeding.
Forms of release: tablets of 0.04 g (40 mg) (N. 50); Capsules of 0.01; 0.04 and 0.1 g (N. 20).
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