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Description of the medicine: Mesalazine (Mesalazine)

MESALAZINE (Mesalazine). 5-aminosalicylic acid.

Synonyms: Asacol, Asalit, Claversal, Fisalamin, Mesacol, Tidocol, Salofalk, etc.

The structure is close to PARA-amino-salicylic acid (PASK; see Sodium PARA-aminosalicylate). It differs in the position of the NH 2 group. It does not have antituberculous activity; it is used to treat acute ulcerative colitis and Crohn's disease. Is an integral part of the molecules of salazosulfapyridine (see) and its analogues, also used for ulcerative colitis and Crohn's disease.

Like other salicylates, mesalazine is an inhibitor of prostaglandin synthesis and has anti-inflammatory activity. It is possible that this plays a role in its specific action. In the body, mesalazine is metabolized, forming N-acetyl-5-aminosalicylic acid.

Mesalazine is prescribed orally in the form of tablets of 0.4 g (400 mg) 3-6 times a day.

When using the drug, nausea, diarrhea, pain in the stomach are possible.

Mesalazine can be used with insufficient efficacy and poor tolerance of salazosulfapyridine (sulfasalazine).

Mesalazine enhances the sugar-lowering effect of sulfonamides, the effects of coumarins, methotrexate, spironolactone, sulfinpyrazone, furosemide, rifampicin. Enhances the ulcerogenic effect of glucoscorticoids on the gastric mucosa.

Contraindicated in case of hypersensitivity to salicylates, with severe violations of the liver and kidneys, with peptic ulcer of the stomach and duodenum.

Pregnant women are prescribed only for health reasons. Should not be prescribed to nursing mothers and children.

Release form: coated tablets of 0.4 g (400 mg).