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Medication Description: Mesalazine (Mesalazine)

Mesalazine. 5-aminosalicylic acid.

Synonyms: Asacol, Asalit, Claversal, Fisalamin, Mesacol, Tidocol, Salofalk, etc.

The structure is close to PA-amino salicylic acid (PAS; see Sodium PA-aminosalicylate). It differs in the position of NH 2 - group. Does not possess anti-tuberculosis activity, is used to treat acute ulcerative colitis and Crohn's disease. It is an integral part of the molecules of salazosulfapyridine (see) and its analogues, also used in ulcerative colitis and Crohn's disease.

Like other salicylates, mesalazine is an inhibitor of prostaglandin synthesis and has anti-inflammatory activity. It is possible that this plays a certain role in its specific action. In the body, mesalazine is metabolized to form N-acetyl-5-aminosalicylic acid.

Prescribed mesalazine inside in the form of tablets of 0.4 g (400 mg) 3-6 times a day.

When using the drug may nausea, diarrhea, pain in the stomach.

Mesalazine can be used with insufficient efficacy and poor tolerability of salazosulfapyridine (sulfasalazine).

Mesalazine enhances the sugar-lowering effect of sulfonamides, the effects of coumarins, methotrexate, spironolactone, sulfinpyrazone, furosemide, rifampicin. Enhances the ulcerogenic effect of glucocorticoids on the gastric mucosa.

Contraindicated in case of hypersensitivity to salicylates, with marked disorders of the liver and kidneys, with gastric ulcer and duodenal ulcer.

Pregnant women are prescribed only for health reasons. Should not be prescribed to nursing mothers and children.

Product form: 0.4 g tablets (400 mg), coated.