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Description of the medicine: Meropenem (Meropenem)

Meropenem.

Synonym: Meronem, Meronem.

By structure and action is close to imipenem.

Compared with the latter, meropenem is more resistant to the action of renal dihydropeptidase. In this regard, can be used (in contrast to imipenem) without the addition of a dihydropeptidase inhibitor - cilastatin.

Meropenem, like imipenem, blocks the synthesis of the cell wall of microbes.

It has a wide spectrum of bactericidal action. It affects most gram-negative and gram-positive, aerobic and anaerobic bacteria. Resistant to the action of β-lactamases.

Applied with a wide range of infections (lower respiratory tract, urinary tract, abdominal cavity organs, skin, soft tissues, bones and joints, gynecological infections, sepsis, meningitis, endocarditis, etc.), including severe ones caused by multiresistant microorganisms. It can be used for "empirical" chemotherapy.

Assign intravenously and intramuscularly.

Intravenous drip (in the form of infusion) or bolus adults 0.5 g every 6 hours or 1 g every 8 hours; Children - at the rate of 10-20 mg / kg 3 times a day. The average duration of treatment is 10-14 days. For particularly severe infections (meningitis), the dose for adults can be increased to 6 g per day (about 120 mg / kg per day); For children weighing over 50 kg - up to 40 mg / kg 3 times a day.

With bolus administration (within 5 minutes), 0.25 g of the drug is dissolved in 5 ml of isotonic sodium chloride solution or 5% glucose solution, with infusion (for 15-30 minutes) - in 50-250 ml of the solvent.

Intramuscularly injected at 1-1.5 grams per day (in 2-3 divided doses).

The solutions are prepared ex tempore.

When using the drug are possible: headache, paresthesia, dyspepsia, liver dysfunction, candidiasis, leukopenia, neutropenia, thrombocytopenia, thrombophlebitis, allergic reactions and other side effects.

Form release: powder for injection solutions in vials of 0.5 or 1 g.

Storage: List B.