Description of the medicine: Butadionum

BUTADION (Butadionum). 1, 2-Diphenyl-4-butylpyrazolidinedione 3, 5.

Synonyms: Alindor, Antadol, Arthril, Arihrizon, Artrizin, Artropan, Azobutil, Butalan, Butalgin, Butalidon, Butapirazol, Butartril, Butazolidin, Butazone, Butofar, Butosal, Butylpyrin, Colbutan, Curozoladin, Delbutan, Deltabutanyl, Dibutone, Diphenylbutazon, Elmedal, Eributazone, Fenibutasan, Fenilbutazona, Fenylbutazon, Mephabutazon, Merizone, Nadozone, Novophenyl, Panazone, Phebutan, Phenbutazol, Phenopyrine, Phenylbutazon, Phenylbutazonum, Rheumaphen, Rubatone, Sedazole, Todalgil, Zolaphen and others.

White or white with a slightly yellowish tinge powder. Almost nerastvorim in water, it is difficult soluble in alcohol; Soluble in sodium hydroxide solution. By chemical structure, butadione is a derivative of antipyrine and is close to amidopyrine. Has analgesic, antipyretic and anti-inflammatory effect; But for anti-inflammatory activity is much superior to antipyrine and amidopyrine and is therefore considered as one of the main representatives of non-steroidal anti-inflammatory drugs.

Butadione is a relatively strong inhibitor of prostaglandin biosynthesis, exceeding in this respect acetylsalicylic acid.

The drug is quickly absorbed and relatively long in the blood.

Applied for the treatment of acute rheumatism, acute, subacute and chronic rheumatoid polyarthritis, infectious nonspecific polyarthritis, Bechterew's disease, gout, psoriatic arthritis, erythema nodosum, small chorea.

Butadione can be used in combination with hormonal drugs (corticosteroids), hingamine (see).

With arthritis of different etiology, butadion quickly reduces pain and inflammatory response; It also stops bouts of gout, reduces the content of uric acid in the blood. There are data on the efficacy of butadione in thrombophlebitis of the veins of the lower limbs and hemorrhoidal veins: application of the drug causes a reduction in pain, swelling, and hyperemia and a significant improvement in the general condition (for these diseases, an ointment containing butadion can be used). There are also indications of a positive effect of butadione in lupus erythematosus. A good effect (reduction of exudation and pain) is noted in iridocyclitis.

Assign butadion inside during or after a meal. Single dose for adults 0.1 - 0.15 g; During the day the drug is taken 2 to 3 times; Daily dose of 0.45 - 0.6 g. After the onset of a noticeable improvement, the dose can be gradually reduced to 0.3-0.2 g. Children (aged 6 months) are prescribed 3 to 4 times a day for 0.01-0 , 1 g, depending on age. The duration of the course of treatment depends on the features of the case and can reach 2 to 5 weeks or more.

Possible combined use of butadione with other non-steroidal anti-inflammatory drugs.

Higher doses of butadione for adults inside: single 0.2 g, daily 0.6 g.

In the treatment of butadion, side effects can occur relatively frequently: fluid retention in the body, nausea, vomiting, stomach pain (the drug has ulcerogenic effect), frequent stools, skin rash, itching, urticaria, leukopenia (agranulocytosis) and anemia, hemorrhage (hematuria ), Neuritis, etc.