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Description of the medicine: Norfloxacin (Norfloxacin)

NORFLOXACIN (Norfloxacin).

1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -3-quinoline carboxylic acid.

Synonyms: Anquin, Bactinor, Girablok, Quinolox, Loxon, Negaflox, Nolitsin, Norbactin, Norilet, Normax, Noroxin, Norflox, Renor, Sofazin, Spectrum, Chibroxin, Utibid, Anquin, Baccidal, Bactinroin, Bactinor, Bzcinben, Esquinor, Baccinor, Bz Chinrox, Baccinor, Bquinxen Floxacin, Fulgram, Girabloc, Lexinor, Loxon, Negaflox, Nolicin, Nolion, Norbactin, Norfaxin, Norilet, Normax, Norocin, Noroxin, Primoxin, Renor, Sofazin, Spectrama, Uroctal, Utibid, Zoroxin, etc.

It differs in chemical structure from pefloxacin by the absence of a methyl group in the piperazinyl nucleus.

Active against most gram-negative and some gram-positive (staphylococci) bacteria. Does not affect anaerobes.

Absorbed quickly, but not completely (20-40% of the dose), C max is 60-90 min, T Ѕ - 2.5-4.5 hours; penetrates well into organs and tissues; undergoes slight biotransformation in the liver, excreted in the urine mainly unchanged.

Used for urinary tract infections, intestinal infections (shigellosis, salmonellosis), eye infections, with otitis media, prostatitis and gonorrhea.

Assign inside and topically.

Inside (1 hour before or 2 hours after eating), 0.2-0.4 g is usually used 2-3 times a day for 7-10 days (in case of chronic recurrent urinary tract infection - up to 12 weeks); in acute gonococcal urethritis, pharyngitis, proctitis, cervicitis - 0.8 g once.

Locally prescribed 1-2 drops of the affected eye every 2 hours or 4 times a day and 4 drops in each ear 3-4 times a day.

It can cause side effects from the gastrointestinal tract (dyspepsia), urinary tract (dysuria), central nervous system (insomnia, hallucinations), the cardiovascular system (tachycardia, arrhythmias, hypotension), as well as dysbiosis, candidiasis, leukopenia, skin allergic reactions.

The drug is contraindicated in severe renal failure, pregnancy, breast-feeding and under the age of 15 years.

Method of release: tablets of 0.2; 0.4 and 0.8 g (N. 10, 20); 0.3% solution (eye and ear drops) in 5 ml dropper bottles (Normax).

Storage: List B.