Medication Description: Norfloxacin
1-Ethyl-6-fluoro-1,4-dihydro-4-oxo-7- (1-piperazinyl) -3-quinoline-carboxylic acid.
Synonyms: Anquin, Baktinor, Girablok, Quinolox, Lokson, Negaflox, Nycin, Norbaktin, Noriloks, Norfox, Norflox, Renor, Sofazin, Spectrama, Cibroxin, Anibin, Anne Floxacin, Fulgram, Girabloc, Lexinor, Loxon, Negaflox, Nolicin, Nolion, Norbactin, Norfaxin, Norilet, Normax, Norocin, Noroxin, Primoxin, Renor, Sofazin, Spectrama, Uroctal, Utibid, Zoroxin, etc.
It differs in chemical structure from pefloxacin in the absence of a methyl group in the piperazinyl core.
It is active against most gram-negative and some gram-positive (staphylococcal) bacteria. Does not affect anaerobes.
It is absorbed quickly, but not completely (20-40% of the dose), C max is 60-90 min, T Ѕ - 2.5-4.5 h; penetrates organs and tissues well; undergoes minor biotransformation in the liver, is excreted in the urine mostly unchanged.
Applied with urinary tract infections, intestinal infections (shigellosis, salmonellosis), eye infections, otitis, prostatitis and gonorrhea.
Assign inside and local.
Inside (1 hour before or 2 hours after a meal) usually use 0.2-0.4 g 2-3 times a day for 7-10 days (for chronic recurrent urinary tract infections - up to 12 weeks); with acute gonococcal urethritis, pharyngitis, proctitis, cervicitis - 0.8 g once.
Locally prescribed 1-2 drops of the affected eye every 2 hours or 4 times a day and 4 drops in each ear 3-4 times a day.
May cause side effects from the gastrointestinal tract (dyspepsia), urinary tract (dysuria), central nervous system (insomnia, hallucinations), cardiovascular system (tachycardia, arrhythmias, hypotension), as well as dysbiosis, candidiasis, leukopenia, skin allergic reactions.
The drug is contraindicated in severe renal failure, pregnancy, breastfeeding and under the age of 15 years.
Method of production: tablets of 0.2; 0.4 and 0.8 g (N. 10, 20); 0.3% solution (eye and ear drops) in dropper bottles of 5 ml (Normaks).
Storage: List B.